Amino-acid functionalized porous silicon nanoparticles for the delivery of pDNA

Porous silicon nanoparticles as a novel platform in gene therapy, have shown to be an efficient vehicle for the delivery of nucleic acids in cells. For the first time, a family of porous silicon nanoparticles has been produced featuring an amino-acid functionalized cationic external surface aiming a...

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Autores principales: Chaix, Arnaud, Cueto-Diaz, Eduardo, Delalande, Anthony, Knezevic, Nikola, Midoux, Patrick, Durand, Jean-Olivier, Pichon, Chantal, Cunin, Frederique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072902/
https://www.ncbi.nlm.nih.gov/pubmed/35530795
http://dx.doi.org/10.1039/c9ra05461h
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author Chaix, Arnaud
Cueto-Diaz, Eduardo
Delalande, Anthony
Knezevic, Nikola
Midoux, Patrick
Durand, Jean-Olivier
Pichon, Chantal
Cunin, Frederique
author_facet Chaix, Arnaud
Cueto-Diaz, Eduardo
Delalande, Anthony
Knezevic, Nikola
Midoux, Patrick
Durand, Jean-Olivier
Pichon, Chantal
Cunin, Frederique
author_sort Chaix, Arnaud
collection PubMed
description Porous silicon nanoparticles as a novel platform in gene therapy, have shown to be an efficient vehicle for the delivery of nucleic acids in cells. For the first time, a family of porous silicon nanoparticles has been produced featuring an amino-acid functionalized cationic external surface aiming at pDNA complexation. The amino acid-based pDNA nanocarriers, displaying an average diameter of 295 nm, succeeded in transfection of HEK293 cells with an efficiency 300 times superior to “bare” porous silicon nanoparticles.
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spelling pubmed-90729022022-05-06 Amino-acid functionalized porous silicon nanoparticles for the delivery of pDNA Chaix, Arnaud Cueto-Diaz, Eduardo Delalande, Anthony Knezevic, Nikola Midoux, Patrick Durand, Jean-Olivier Pichon, Chantal Cunin, Frederique RSC Adv Chemistry Porous silicon nanoparticles as a novel platform in gene therapy, have shown to be an efficient vehicle for the delivery of nucleic acids in cells. For the first time, a family of porous silicon nanoparticles has been produced featuring an amino-acid functionalized cationic external surface aiming at pDNA complexation. The amino acid-based pDNA nanocarriers, displaying an average diameter of 295 nm, succeeded in transfection of HEK293 cells with an efficiency 300 times superior to “bare” porous silicon nanoparticles. The Royal Society of Chemistry 2019-10-07 /pmc/articles/PMC9072902/ /pubmed/35530795 http://dx.doi.org/10.1039/c9ra05461h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Chaix, Arnaud
Cueto-Diaz, Eduardo
Delalande, Anthony
Knezevic, Nikola
Midoux, Patrick
Durand, Jean-Olivier
Pichon, Chantal
Cunin, Frederique
Amino-acid functionalized porous silicon nanoparticles for the delivery of pDNA
title Amino-acid functionalized porous silicon nanoparticles for the delivery of pDNA
title_full Amino-acid functionalized porous silicon nanoparticles for the delivery of pDNA
title_fullStr Amino-acid functionalized porous silicon nanoparticles for the delivery of pDNA
title_full_unstemmed Amino-acid functionalized porous silicon nanoparticles for the delivery of pDNA
title_short Amino-acid functionalized porous silicon nanoparticles for the delivery of pDNA
title_sort amino-acid functionalized porous silicon nanoparticles for the delivery of pdna
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072902/
https://www.ncbi.nlm.nih.gov/pubmed/35530795
http://dx.doi.org/10.1039/c9ra05461h
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