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Palladium-catalyzed oxidative cross-coupling for the synthesis of α-amino ketones
A novel oxidative cross-coupling reaction for the synthesis of α-aryl α-amino ketones in the presence of palladium catalysts using T(+)BF(4)(−) as an oxidant has been developed. This transformation was achieved by direct C–H oxidation of α-aminocarbonyl compounds and arylation. The mild reaction has...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072988/ https://www.ncbi.nlm.nih.gov/pubmed/35530775 http://dx.doi.org/10.1039/c9ra06108h |
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| author | Wei, Xiao-Hong Li, Zhen-Hua Zhao, Lian-Biao Zhang, Ping Zhou, Han-Cheng Wang, Yan-Bin |
| author_facet | Wei, Xiao-Hong Li, Zhen-Hua Zhao, Lian-Biao Zhang, Ping Zhou, Han-Cheng Wang, Yan-Bin |
| author_sort | Wei, Xiao-Hong |
| collection | PubMed |
| description | A novel oxidative cross-coupling reaction for the synthesis of α-aryl α-amino ketones in the presence of palladium catalysts using T(+)BF(4)(−) as an oxidant has been developed. This transformation was achieved by direct C–H oxidation of α-aminocarbonyl compounds and arylation. The mild reaction has a broad reaction scope and gives desired α-aryl α-amino ketones in moderate to excellent yields. |
| format | Online Article Text |
| id | pubmed-9072988 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | The Royal Society of Chemistry |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-90729882022-05-06 Palladium-catalyzed oxidative cross-coupling for the synthesis of α-amino ketones Wei, Xiao-Hong Li, Zhen-Hua Zhao, Lian-Biao Zhang, Ping Zhou, Han-Cheng Wang, Yan-Bin RSC Adv Chemistry A novel oxidative cross-coupling reaction for the synthesis of α-aryl α-amino ketones in the presence of palladium catalysts using T(+)BF(4)(−) as an oxidant has been developed. This transformation was achieved by direct C–H oxidation of α-aminocarbonyl compounds and arylation. The mild reaction has a broad reaction scope and gives desired α-aryl α-amino ketones in moderate to excellent yields. The Royal Society of Chemistry 2019-10-09 /pmc/articles/PMC9072988/ /pubmed/35530775 http://dx.doi.org/10.1039/c9ra06108h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
| spellingShingle | Chemistry Wei, Xiao-Hong Li, Zhen-Hua Zhao, Lian-Biao Zhang, Ping Zhou, Han-Cheng Wang, Yan-Bin Palladium-catalyzed oxidative cross-coupling for the synthesis of α-amino ketones |
| title | Palladium-catalyzed oxidative cross-coupling for the synthesis of α-amino ketones |
| title_full | Palladium-catalyzed oxidative cross-coupling for the synthesis of α-amino ketones |
| title_fullStr | Palladium-catalyzed oxidative cross-coupling for the synthesis of α-amino ketones |
| title_full_unstemmed | Palladium-catalyzed oxidative cross-coupling for the synthesis of α-amino ketones |
| title_short | Palladium-catalyzed oxidative cross-coupling for the synthesis of α-amino ketones |
| title_sort | palladium-catalyzed oxidative cross-coupling for the synthesis of α-amino ketones |
| topic | Chemistry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072988/ https://www.ncbi.nlm.nih.gov/pubmed/35530775 http://dx.doi.org/10.1039/c9ra06108h |
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