TFE3-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour

TFE3-rearranged renal cell carcinoma (RCC) is a rare but well characterised histological subtype of RCC with an aggressive clinical course and propensity for late metastases. Osseous metaplasia is an uncommon but well documented finding in clear cell, papillary and chromophobe RCC. We present the fi...

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Autores principales: Aldera, Alessandro Pietro, Ramburan, Amsha, John, Jeff
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073298/
https://www.ncbi.nlm.nih.gov/pubmed/35530544
http://dx.doi.org/10.1016/j.eucr.2022.102041
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author Aldera, Alessandro Pietro
Ramburan, Amsha
John, Jeff
author_facet Aldera, Alessandro Pietro
Ramburan, Amsha
John, Jeff
author_sort Aldera, Alessandro Pietro
collection PubMed
description TFE3-rearranged renal cell carcinoma (RCC) is a rare but well characterised histological subtype of RCC with an aggressive clinical course and propensity for late metastases. Osseous metaplasia is an uncommon but well documented finding in clear cell, papillary and chromophobe RCC. We present the first case of a TFE3-rearranged RCC to be found harbouring metaplastic bone in a 47-year-old woman who presented with a slowly enlarging left flank mass over a 10 year period. This case report adds to the clinicopathological description of TFE3-rearranged RCC and suggests that larger studies are required to fully elucidate the prognosis of these tumours.
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spelling pubmed-90732982022-05-07 TFE3-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour Aldera, Alessandro Pietro Ramburan, Amsha John, Jeff Urol Case Rep Oncology TFE3-rearranged renal cell carcinoma (RCC) is a rare but well characterised histological subtype of RCC with an aggressive clinical course and propensity for late metastases. Osseous metaplasia is an uncommon but well documented finding in clear cell, papillary and chromophobe RCC. We present the first case of a TFE3-rearranged RCC to be found harbouring metaplastic bone in a 47-year-old woman who presented with a slowly enlarging left flank mass over a 10 year period. This case report adds to the clinicopathological description of TFE3-rearranged RCC and suggests that larger studies are required to fully elucidate the prognosis of these tumours. Elsevier 2022-02-25 /pmc/articles/PMC9073298/ /pubmed/35530544 http://dx.doi.org/10.1016/j.eucr.2022.102041 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Oncology
Aldera, Alessandro Pietro
Ramburan, Amsha
John, Jeff
TFE3-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour
title TFE3-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour
title_full TFE3-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour
title_fullStr TFE3-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour
title_full_unstemmed TFE3-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour
title_short TFE3-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour
title_sort tfe3-rearranged renal cell carcinoma with osseous metaplasia and indolent behaviour
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073298/
https://www.ncbi.nlm.nih.gov/pubmed/35530544
http://dx.doi.org/10.1016/j.eucr.2022.102041
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AT ramburanamsha tfe3rearrangedrenalcellcarcinomawithosseousmetaplasiaandindolentbehaviour
AT johnjeff tfe3rearrangedrenalcellcarcinomawithosseousmetaplasiaandindolentbehaviour

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