Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging

A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles via a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiola...

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Detalles Bibliográficos
Autores principales: Thakare, Vivek, Tran, Vu-Long, Natuzzi, Marco, Thomas, Eloïse, Moreau, Mathieu, Romieu, Anthony, Collin, Bertrand, Courteau, Alan, Vrigneaud, Jean-Marc, Louis, Cédric, Roux, Stéphane, Boschetti, Frédéric, Tillement, Olivier, Lux, François, Denat, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073358/
https://www.ncbi.nlm.nih.gov/pubmed/35528689
http://dx.doi.org/10.1039/c9ra00365g
Descripción
Sumario:A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles via a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with (64)Cu, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging.

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