Cargando…
Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging
A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles via a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiola...
| Autores principales: | , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073358/ https://www.ncbi.nlm.nih.gov/pubmed/35528689 http://dx.doi.org/10.1039/c9ra00365g |
| _version_ | 1784701267700875264 |
|---|---|
| author | Thakare, Vivek Tran, Vu-Long Natuzzi, Marco Thomas, Eloïse Moreau, Mathieu Romieu, Anthony Collin, Bertrand Courteau, Alan Vrigneaud, Jean-Marc Louis, Cédric Roux, Stéphane Boschetti, Frédéric Tillement, Olivier Lux, François Denat, Franck |
| author_facet | Thakare, Vivek Tran, Vu-Long Natuzzi, Marco Thomas, Eloïse Moreau, Mathieu Romieu, Anthony Collin, Bertrand Courteau, Alan Vrigneaud, Jean-Marc Louis, Cédric Roux, Stéphane Boschetti, Frédéric Tillement, Olivier Lux, François Denat, Franck |
| author_sort | Thakare, Vivek |
| collection | PubMed |
| description | A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles via a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with (64)Cu, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging. |
| format | Online Article Text |
| id | pubmed-9073358 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | The Royal Society of Chemistry |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-90733582022-05-06 Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging Thakare, Vivek Tran, Vu-Long Natuzzi, Marco Thomas, Eloïse Moreau, Mathieu Romieu, Anthony Collin, Bertrand Courteau, Alan Vrigneaud, Jean-Marc Louis, Cédric Roux, Stéphane Boschetti, Frédéric Tillement, Olivier Lux, François Denat, Franck RSC Adv Chemistry A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles via a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with (64)Cu, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging. The Royal Society of Chemistry 2019-08-09 /pmc/articles/PMC9073358/ /pubmed/35528689 http://dx.doi.org/10.1039/c9ra00365g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
| spellingShingle | Chemistry Thakare, Vivek Tran, Vu-Long Natuzzi, Marco Thomas, Eloïse Moreau, Mathieu Romieu, Anthony Collin, Bertrand Courteau, Alan Vrigneaud, Jean-Marc Louis, Cédric Roux, Stéphane Boschetti, Frédéric Tillement, Olivier Lux, François Denat, Franck Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging |
| title | Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging |
| title_full | Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging |
| title_fullStr | Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging |
| title_full_unstemmed | Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging |
| title_short | Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging |
| title_sort | functionalization of theranostic aguix® nanoparticles for pet/mri/optical imaging |
| topic | Chemistry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073358/ https://www.ncbi.nlm.nih.gov/pubmed/35528689 http://dx.doi.org/10.1039/c9ra00365g |
| work_keys_str_mv | AT thakarevivek functionalizationoftheranosticaguixnanoparticlesforpetmriopticalimaging AT tranvulong functionalizationoftheranosticaguixnanoparticlesforpetmriopticalimaging AT natuzzimarco functionalizationoftheranosticaguixnanoparticlesforpetmriopticalimaging AT thomaseloise functionalizationoftheranosticaguixnanoparticlesforpetmriopticalimaging AT moreaumathieu functionalizationoftheranosticaguixnanoparticlesforpetmriopticalimaging AT romieuanthony functionalizationoftheranosticaguixnanoparticlesforpetmriopticalimaging AT collinbertrand functionalizationoftheranosticaguixnanoparticlesforpetmriopticalimaging AT courteaualan functionalizationoftheranosticaguixnanoparticlesforpetmriopticalimaging AT vrigneaudjeanmarc functionalizationoftheranosticaguixnanoparticlesforpetmriopticalimaging AT louiscedric functionalizationoftheranosticaguixnanoparticlesforpetmriopticalimaging AT rouxstephane functionalizationoftheranosticaguixnanoparticlesforpetmriopticalimaging AT boschettifrederic functionalizationoftheranosticaguixnanoparticlesforpetmriopticalimaging AT tillementolivier functionalizationoftheranosticaguixnanoparticlesforpetmriopticalimaging AT luxfrancois functionalizationoftheranosticaguixnanoparticlesforpetmriopticalimaging AT denatfranck functionalizationoftheranosticaguixnanoparticlesforpetmriopticalimaging |