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Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta-analysis
Overexpression of Ki67 is observed in tumor cells, and it has been suggested to be a marker for cancer prognosis. However, the relationship between Ki67 expression and the risk of recurrence of gastrointestinal stromal tumors (GISTs) remains poorly defined. In the present study, a meta-analysis was...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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D.A. Spandidos
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073573/ https://www.ncbi.nlm.nih.gov/pubmed/35527778 http://dx.doi.org/10.3892/ol.2022.13309 |
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author | Li, Ji Wang, An-Ran Chen, Xiao-Dong Pan, Hong Li, Shi-Qiang |
author_facet | Li, Ji Wang, An-Ran Chen, Xiao-Dong Pan, Hong Li, Shi-Qiang |
author_sort | Li, Ji |
collection | PubMed |
description | Overexpression of Ki67 is observed in tumor cells, and it has been suggested to be a marker for cancer prognosis. However, the relationship between Ki67 expression and the risk of recurrence of gastrointestinal stromal tumors (GISTs) remains poorly defined. In the present study, a meta-analysis was used to examine the associations between Ki67 levels and GIST recurrence. Studies reporting GIST and Ki67 were found by searching Cochrane Library, PubMed and Embase until October 14, 2021. The Newcastle-Ottawa Scale (NOS) was used to verify the quality of the evidence. Totally, 1682 patient cases were included. The odds ratio (OR) estimates and 95% confidence interval (CI) for each publication were determined by a fixed-effects (Mantel-Haenszel) model. A total of 20 studies that fulfilled the inclusion criteria were finally included in the analysis. The average score of quality evaluation was 6.4 points according to NOS. It was found that Ki67 levels were significantly higher in the NIH L group compared with the NIH VL group (OR: 0.51; 95% CI: 0.26-0.99; P=0.04; P heterogeneity=0.44). There was also greater Ki67 overexpression in the NIH I group compared with the NIH L group (OR: 0.45, 95% CI: 0.31-0.65; P<0.0001; P heterogeneity=0.32), while Ki67 levels were greater in the NIH H group than in the NIH I group (OR: 0.20; 95% CI: 0.15-0.28; P<0.00001; P heterogeneity=0.56). In conclusion, Ki67 overexpression may be a useful marker of the risk of recurrent GIST transformation. |
format | Online Article Text |
id | pubmed-9073573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-90735732022-05-07 Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta-analysis Li, Ji Wang, An-Ran Chen, Xiao-Dong Pan, Hong Li, Shi-Qiang Oncol Lett Articles Overexpression of Ki67 is observed in tumor cells, and it has been suggested to be a marker for cancer prognosis. However, the relationship between Ki67 expression and the risk of recurrence of gastrointestinal stromal tumors (GISTs) remains poorly defined. In the present study, a meta-analysis was used to examine the associations between Ki67 levels and GIST recurrence. Studies reporting GIST and Ki67 were found by searching Cochrane Library, PubMed and Embase until October 14, 2021. The Newcastle-Ottawa Scale (NOS) was used to verify the quality of the evidence. Totally, 1682 patient cases were included. The odds ratio (OR) estimates and 95% confidence interval (CI) for each publication were determined by a fixed-effects (Mantel-Haenszel) model. A total of 20 studies that fulfilled the inclusion criteria were finally included in the analysis. The average score of quality evaluation was 6.4 points according to NOS. It was found that Ki67 levels were significantly higher in the NIH L group compared with the NIH VL group (OR: 0.51; 95% CI: 0.26-0.99; P=0.04; P heterogeneity=0.44). There was also greater Ki67 overexpression in the NIH I group compared with the NIH L group (OR: 0.45, 95% CI: 0.31-0.65; P<0.0001; P heterogeneity=0.32), while Ki67 levels were greater in the NIH H group than in the NIH I group (OR: 0.20; 95% CI: 0.15-0.28; P<0.00001; P heterogeneity=0.56). In conclusion, Ki67 overexpression may be a useful marker of the risk of recurrent GIST transformation. D.A. Spandidos 2022-06 2022-04-27 /pmc/articles/PMC9073573/ /pubmed/35527778 http://dx.doi.org/10.3892/ol.2022.13309 Text en Copyright: © Li et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Li, Ji Wang, An-Ran Chen, Xiao-Dong Pan, Hong Li, Shi-Qiang Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta-analysis |
title | Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta-analysis |
title_full | Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta-analysis |
title_fullStr | Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta-analysis |
title_full_unstemmed | Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta-analysis |
title_short | Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta-analysis |
title_sort | ki67 for evaluating the prognosis of gastrointestinal stromal tumors: a systematic review and meta-analysis |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073573/ https://www.ncbi.nlm.nih.gov/pubmed/35527778 http://dx.doi.org/10.3892/ol.2022.13309 |
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