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The E23K Polymorphism of KCNJ11 and Diabetic Retinopathy in Northern Iran
Background: Diabetic Retinopathy (DR) is one of the most severe micro-vascular complications of diabetes mellitus (DM), involving interactions between environmental and genetic risk factors. KCNJ11 gene has a key role in insulin secretion and is of substantial interest in various populations. Method...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073720/ https://www.ncbi.nlm.nih.gov/pubmed/35996512 http://dx.doi.org/10.3389/bjbs.2021.10245 |
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author | Alidoust, L. Ajamian, F. Abbaspour, S. Sharafshah, A. Keshavarz, P. |
author_facet | Alidoust, L. Ajamian, F. Abbaspour, S. Sharafshah, A. Keshavarz, P. |
author_sort | Alidoust, L. |
collection | PubMed |
description | Background: Diabetic Retinopathy (DR) is one of the most severe micro-vascular complications of diabetes mellitus (DM), involving interactions between environmental and genetic risk factors. KCNJ11 gene has a key role in insulin secretion and is of substantial interest in various populations. Methods: A population-based association of 524 T2DM patients was performed to delineate the genetic influence of KCNJ11 polymorphisms (rs5219, c.67A>G or E23K) on the risk of DR in an Iranian population. Genotyping was performed using TaqMan assay. Univariate and MLR analysis controlling for confounders was conducted to evaluate the association between rs5219 and DR. Results: No significant difference was observed in either genotypes distribution (p = 0.83) or allele frequency (p = 0.66) between T2DM individuals with and without DR in any models of inheritance. Genotype-phenotype association showed that DR group carrying GA genotypes, a significantly higher mean age was observed compared with two other genotypes (p = 0.04). MLR analysis indicated that HbAlc with adjusted OR of 1.84 (95% CI, 1.46–2.33, p = 0.00) and first-degree relatives of family history with adjusted OR of 2.85 (95% CI, 1.45–5.58, p = 0.002) were significantly associated with DR, but the c.67A>G genotype is not an independent predictor of retinopathy. Conclusion: Collectively, rs5219 was not associated with DR among Iranians with T2DM. |
format | Online Article Text |
id | pubmed-9073720 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90737202022-05-07 The E23K Polymorphism of KCNJ11 and Diabetic Retinopathy in Northern Iran Alidoust, L. Ajamian, F. Abbaspour, S. Sharafshah, A. Keshavarz, P. Br J Biomed Sci Health Archive Background: Diabetic Retinopathy (DR) is one of the most severe micro-vascular complications of diabetes mellitus (DM), involving interactions between environmental and genetic risk factors. KCNJ11 gene has a key role in insulin secretion and is of substantial interest in various populations. Methods: A population-based association of 524 T2DM patients was performed to delineate the genetic influence of KCNJ11 polymorphisms (rs5219, c.67A>G or E23K) on the risk of DR in an Iranian population. Genotyping was performed using TaqMan assay. Univariate and MLR analysis controlling for confounders was conducted to evaluate the association between rs5219 and DR. Results: No significant difference was observed in either genotypes distribution (p = 0.83) or allele frequency (p = 0.66) between T2DM individuals with and without DR in any models of inheritance. Genotype-phenotype association showed that DR group carrying GA genotypes, a significantly higher mean age was observed compared with two other genotypes (p = 0.04). MLR analysis indicated that HbAlc with adjusted OR of 1.84 (95% CI, 1.46–2.33, p = 0.00) and first-degree relatives of family history with adjusted OR of 2.85 (95% CI, 1.45–5.58, p = 0.002) were significantly associated with DR, but the c.67A>G genotype is not an independent predictor of retinopathy. Conclusion: Collectively, rs5219 was not associated with DR among Iranians with T2DM. Frontiers Media S.A. 2022-04-22 /pmc/articles/PMC9073720/ /pubmed/35996512 http://dx.doi.org/10.3389/bjbs.2021.10245 Text en Copyright © 2022 Alidoust, Ajamian, Abbaspour, Sharafshah and Keshavarz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Health Archive Alidoust, L. Ajamian, F. Abbaspour, S. Sharafshah, A. Keshavarz, P. The E23K Polymorphism of KCNJ11 and Diabetic Retinopathy in Northern Iran |
title | The E23K Polymorphism of KCNJ11 and Diabetic Retinopathy in Northern Iran |
title_full | The E23K Polymorphism of KCNJ11 and Diabetic Retinopathy in Northern Iran |
title_fullStr | The E23K Polymorphism of KCNJ11 and Diabetic Retinopathy in Northern Iran |
title_full_unstemmed | The E23K Polymorphism of KCNJ11 and Diabetic Retinopathy in Northern Iran |
title_short | The E23K Polymorphism of KCNJ11 and Diabetic Retinopathy in Northern Iran |
title_sort | e23k polymorphism of kcnj11 and diabetic retinopathy in northern iran |
topic | Health Archive |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073720/ https://www.ncbi.nlm.nih.gov/pubmed/35996512 http://dx.doi.org/10.3389/bjbs.2021.10245 |
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