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A β-Catenin-TCF-Sensitive Locus Control Region Mediates GUCY2C Ligand Loss in Colorectal Cancer

BACKGROUND & AIMS: Sporadic colorectal cancers arise from initiating mutations in APC, producing oncogenic β-catenin/TCF–dependent transcriptional reprogramming. Similarly, the tumor suppressor axis regulated by the intestinal epithelial receptor GUCY2C is among the earliest pathways silenced in...

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Detalles Bibliográficos
Autores principales:	Rappaport, Jeffrey A., Entezari, Ariana A., Caspi, Adi, Caksa, Signe, Jhaveri, Aakash V., Stanek, Timothy J., Ertel, Adam, Kupper, Joan, Fortina, Paolo M., McMahon, Steven B., Jaynes, James B., Snook, Adam E., Waldman, Scott A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073733/ https://www.ncbi.nlm.nih.gov/pubmed/34954189 http://dx.doi.org/10.1016/j.jcmgh.2021.12.014

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