Picropodophyllin inhibits the growth of pemetrexed-resistant malignant pleural mesothelioma via microtubule inhibition and IGF-1R-, caspase-independent pathways

BACKGROUND: Acquired pemetrexed resistance leads to treatment interruption in patients with malignant pleural mesothelioma (MPM). Insulin-like growth factor-I receptor (IGF-1R) inhibitor is a candidate for treating pemetrexed-naïve MPM. However, the efficacy of cytotoxic and targeted drugs in acquir...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Rong, Tanino, Ryosuke, Tong, Xuexia, Haque, Eshat Fahmida, Amano, Yoshihiro, Isobe, Takeshi, Tsubata, Yukari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073748/
https://www.ncbi.nlm.nih.gov/pubmed/35529797
http://dx.doi.org/10.21037/tlcr-21-765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073748/
https://www.ncbi.nlm.nih.gov/pubmed/35529797
http://dx.doi.org/10.21037/tlcr-21-765

Ejemplares similares