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Serological response after SARS-CoV2 vaccination in healthcare workers: a multicenter study
INTRODUCTION: Characterizing immunological response following COVID-19 vaccination is an important public health issue. The objectives of the present analysis were to investigate the proportion, level and the determinants of humoral response from 21 days to three months after the first dose in vacci...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mattioli 1885 srl
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073755/ https://www.ncbi.nlm.nih.gov/pubmed/35481576 http://dx.doi.org/10.23749/mdl.v113i2.13017 |
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author | Visci, Giovanni Zunarelli, Carlotta Mansour, Ihab Porru, Stefano De Palma, Giuseppe Duval, Xavier Monaco, Maria Grazia Lourdes Spiteri, Gianluca Carta, Angela Lippi, Giuseppe Verlato, Giuseppe Sansone, Emanuele Sala, Emma Lombardo, Massimo Abedini, Mahsa Violante, Francesco Boffetta, Paolo |
author_facet | Visci, Giovanni Zunarelli, Carlotta Mansour, Ihab Porru, Stefano De Palma, Giuseppe Duval, Xavier Monaco, Maria Grazia Lourdes Spiteri, Gianluca Carta, Angela Lippi, Giuseppe Verlato, Giuseppe Sansone, Emanuele Sala, Emma Lombardo, Massimo Abedini, Mahsa Violante, Francesco Boffetta, Paolo |
author_sort | Visci, Giovanni |
collection | PubMed |
description | INTRODUCTION: Characterizing immunological response following COVID-19 vaccination is an important public health issue. The objectives of the present analysis were to investigate the proportion, level and the determinants of humoral response from 21 days to three months after the first dose in vaccinated healthcare workers (HCWs). METHODS: We abstracted data on level of anti-SARS-CoV-2 Spike antibodies (IgG) and sociodemographic characteristics of 17,257 HCWs from public hospitals and public health authorities from three centers in Northern Italy who underwent COVID-19 vaccination (average 70.6 days after first dose). We fitted center-specific multivariate regression models and combined them using random-effects meta-analyses. RESULTS: A humoral response was elicited in 99.3% of vaccinated HCW. Female sex, young age, and previous COVID-19 infection were predictors of post-vaccination antibody level, and a positive association was also detected with pre-vaccination serology level and with time between pre- and post-vaccination testing, while a decline of antibody level was suggested with time since vaccination. CONCLUSIONS: These results stress the importance of analyzing retrospective data collected via occupational health surveillance of HCWs during the COVID-19 epidemic and following vaccination. They need to be confirmed in larger series based on prospectively collected data. |
format | Online Article Text |
id | pubmed-9073755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Mattioli 1885 srl |
record_format | MEDLINE/PubMed |
spelling | pubmed-90737552022-05-19 Serological response after SARS-CoV2 vaccination in healthcare workers: a multicenter study Visci, Giovanni Zunarelli, Carlotta Mansour, Ihab Porru, Stefano De Palma, Giuseppe Duval, Xavier Monaco, Maria Grazia Lourdes Spiteri, Gianluca Carta, Angela Lippi, Giuseppe Verlato, Giuseppe Sansone, Emanuele Sala, Emma Lombardo, Massimo Abedini, Mahsa Violante, Francesco Boffetta, Paolo Med Lav Original Article INTRODUCTION: Characterizing immunological response following COVID-19 vaccination is an important public health issue. The objectives of the present analysis were to investigate the proportion, level and the determinants of humoral response from 21 days to three months after the first dose in vaccinated healthcare workers (HCWs). METHODS: We abstracted data on level of anti-SARS-CoV-2 Spike antibodies (IgG) and sociodemographic characteristics of 17,257 HCWs from public hospitals and public health authorities from three centers in Northern Italy who underwent COVID-19 vaccination (average 70.6 days after first dose). We fitted center-specific multivariate regression models and combined them using random-effects meta-analyses. RESULTS: A humoral response was elicited in 99.3% of vaccinated HCW. Female sex, young age, and previous COVID-19 infection were predictors of post-vaccination antibody level, and a positive association was also detected with pre-vaccination serology level and with time between pre- and post-vaccination testing, while a decline of antibody level was suggested with time since vaccination. CONCLUSIONS: These results stress the importance of analyzing retrospective data collected via occupational health surveillance of HCWs during the COVID-19 epidemic and following vaccination. They need to be confirmed in larger series based on prospectively collected data. Mattioli 1885 srl 2022 2022-04-26 /pmc/articles/PMC9073755/ /pubmed/35481576 http://dx.doi.org/10.23749/mdl.v113i2.13017 Text en Copyright: © 2022 https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License |
spellingShingle | Original Article Visci, Giovanni Zunarelli, Carlotta Mansour, Ihab Porru, Stefano De Palma, Giuseppe Duval, Xavier Monaco, Maria Grazia Lourdes Spiteri, Gianluca Carta, Angela Lippi, Giuseppe Verlato, Giuseppe Sansone, Emanuele Sala, Emma Lombardo, Massimo Abedini, Mahsa Violante, Francesco Boffetta, Paolo Serological response after SARS-CoV2 vaccination in healthcare workers: a multicenter study |
title | Serological response after SARS-CoV2 vaccination in healthcare workers: a multicenter study |
title_full | Serological response after SARS-CoV2 vaccination in healthcare workers: a multicenter study |
title_fullStr | Serological response after SARS-CoV2 vaccination in healthcare workers: a multicenter study |
title_full_unstemmed | Serological response after SARS-CoV2 vaccination in healthcare workers: a multicenter study |
title_short | Serological response after SARS-CoV2 vaccination in healthcare workers: a multicenter study |
title_sort | serological response after sars-cov2 vaccination in healthcare workers: a multicenter study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073755/ https://www.ncbi.nlm.nih.gov/pubmed/35481576 http://dx.doi.org/10.23749/mdl.v113i2.13017 |
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