Single-Particle Resolution of Copper-Associated Annular α-Synuclein Oligomers Reveals Potential Therapeutic Targets of Neurodegeneration

[Image: see text] Metal ions stabilize protein–protein interactions and can modulate protein aggregation. Here, using liquid-based atomic force microscopy and molecular dynamics simulations, we study the concentration-dependent effect of Cu(2+) ions on the aggregation pathway of α-synuclein (α-Syn)...

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Detalles Bibliográficos
Autores principales: Synhaivska, Olena, Bhattacharya, Shayon, Campioni, Silvia, Thompson, Damien, Nirmalraj, Peter Niraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073932/
https://www.ncbi.nlm.nih.gov/pubmed/35414168
http://dx.doi.org/10.1021/acschemneuro.2c00021

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