The functional roles of the circRNA/Wnt axis in cancer

CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt pathway. Aberrant Wnt pathway activation is involved in the development of various types of cancers. Accumulating evidence indicate...

Descripción completa

Detalles Bibliográficos
Autores principales: Xue, Chen, Li, Ganglei, Zheng, Qiuxian, Gu, Xinyu, Bao, Zhengyi, Lu, Juan, Li, Lanjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074313/
https://www.ncbi.nlm.nih.gov/pubmed/35513849
http://dx.doi.org/10.1186/s12943-022-01582-0
_version_ 1784701457513054208
author Xue, Chen
Li, Ganglei
Zheng, Qiuxian
Gu, Xinyu
Bao, Zhengyi
Lu, Juan
Li, Lanjuan
author_facet Xue, Chen
Li, Ganglei
Zheng, Qiuxian
Gu, Xinyu
Bao, Zhengyi
Lu, Juan
Li, Lanjuan
author_sort Xue, Chen
collection PubMed
description CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt pathway. Aberrant Wnt pathway activation is involved in the development of various types of cancers. Accumulating evidence indicates that the circRNA/Wnt axis modulates the expression of cancer-associated genes and then regulates cancer progression. Wnt pathway-related circRNA expression is obviously associated with many clinical characteristics. CircRNAs could regulate cell biological functions by interacting with the Wnt pathway. Moreover, Wnt pathway-related circRNAs are promising potential biomarkers for cancer diagnosis, prognosis evaluation, and treatment. In our review, we summarized the recent research progress on the role and clinical application of Wnt pathway-related circRNAs in tumorigenesis and progression.
format Online
Article
Text
id pubmed-9074313
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-90743132022-05-07 The functional roles of the circRNA/Wnt axis in cancer Xue, Chen Li, Ganglei Zheng, Qiuxian Gu, Xinyu Bao, Zhengyi Lu, Juan Li, Lanjuan Mol Cancer Review CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt pathway. Aberrant Wnt pathway activation is involved in the development of various types of cancers. Accumulating evidence indicates that the circRNA/Wnt axis modulates the expression of cancer-associated genes and then regulates cancer progression. Wnt pathway-related circRNA expression is obviously associated with many clinical characteristics. CircRNAs could regulate cell biological functions by interacting with the Wnt pathway. Moreover, Wnt pathway-related circRNAs are promising potential biomarkers for cancer diagnosis, prognosis evaluation, and treatment. In our review, we summarized the recent research progress on the role and clinical application of Wnt pathway-related circRNAs in tumorigenesis and progression. BioMed Central 2022-05-05 /pmc/articles/PMC9074313/ /pubmed/35513849 http://dx.doi.org/10.1186/s12943-022-01582-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Xue, Chen
Li, Ganglei
Zheng, Qiuxian
Gu, Xinyu
Bao, Zhengyi
Lu, Juan
Li, Lanjuan
The functional roles of the circRNA/Wnt axis in cancer
title The functional roles of the circRNA/Wnt axis in cancer
title_full The functional roles of the circRNA/Wnt axis in cancer
title_fullStr The functional roles of the circRNA/Wnt axis in cancer
title_full_unstemmed The functional roles of the circRNA/Wnt axis in cancer
title_short The functional roles of the circRNA/Wnt axis in cancer
title_sort functional roles of the circrna/wnt axis in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074313/
https://www.ncbi.nlm.nih.gov/pubmed/35513849
http://dx.doi.org/10.1186/s12943-022-01582-0
work_keys_str_mv AT xuechen thefunctionalrolesofthecircrnawntaxisincancer
AT liganglei thefunctionalrolesofthecircrnawntaxisincancer
AT zhengqiuxian thefunctionalrolesofthecircrnawntaxisincancer
AT guxinyu thefunctionalrolesofthecircrnawntaxisincancer
AT baozhengyi thefunctionalrolesofthecircrnawntaxisincancer
AT lujuan thefunctionalrolesofthecircrnawntaxisincancer
AT lilanjuan thefunctionalrolesofthecircrnawntaxisincancer
AT xuechen functionalrolesofthecircrnawntaxisincancer
AT liganglei functionalrolesofthecircrnawntaxisincancer
AT zhengqiuxian functionalrolesofthecircrnawntaxisincancer
AT guxinyu functionalrolesofthecircrnawntaxisincancer
AT baozhengyi functionalrolesofthecircrnawntaxisincancer
AT lujuan functionalrolesofthecircrnawntaxisincancer
AT lilanjuan functionalrolesofthecircrnawntaxisincancer

Ejemplares similares