Cargando…
A propensity score-matched analysis of the impact of statin therapy on the outcomes of patients with non-small-cell lung cancer receiving anti-PD-1 monotherapy: a multicenter retrospective study
BACKGROUND: Many studies have recently reported the association of concomitant medications with the response and survival in patients with non-small-cell lung cancer (NSCLC) treated with cancer immunotherapy. However, the clinical impact of statin therapy on the outcome of cancer immunotherapy in pa...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074359/ https://www.ncbi.nlm.nih.gov/pubmed/35524214 http://dx.doi.org/10.1186/s12885-022-09385-8 |
_version_ | 1784701466301169664 |
---|---|
author | Takada, Kazuki Shimokawa, Mototsugu Takamori, Shinkichi Shimamatsu, Shinichiro Hirai, Fumihiko Tagawa, Tetsuzo Okamoto, Tatsuro Hamatake, Motoharu Tsuchiya-Kawano, Yuko Otsubo, Kohei Inoue, Koji Yoneshima, Yasuto Tanaka, Kentaro Okamoto, Isamu Nakanishi, Yoichi Mori, Masaki |
author_facet | Takada, Kazuki Shimokawa, Mototsugu Takamori, Shinkichi Shimamatsu, Shinichiro Hirai, Fumihiko Tagawa, Tetsuzo Okamoto, Tatsuro Hamatake, Motoharu Tsuchiya-Kawano, Yuko Otsubo, Kohei Inoue, Koji Yoneshima, Yasuto Tanaka, Kentaro Okamoto, Isamu Nakanishi, Yoichi Mori, Masaki |
author_sort | Takada, Kazuki |
collection | PubMed |
description | BACKGROUND: Many studies have recently reported the association of concomitant medications with the response and survival in patients with non-small-cell lung cancer (NSCLC) treated with cancer immunotherapy. However, the clinical impact of statin therapy on the outcome of cancer immunotherapy in patients with NSCLC is poorly understood. METHODS: In our database, we retrospectively identified and enrolled 390 patients with advanced or recurrent NSCLC who were treated with anti-programmed cell death-1 (PD-1) monotherapy in clinical practice between January 2016 and December 2019 at 3 medical centers in Japan to examine the clinical impact of statin therapy on the survival of patients with NSCLC receiving anti-PD-1 monotherapy. A propensity score-matched analysis was conducted to minimize the bias arising from the patients’ backgrounds. RESULTS: The Kaplan–Meier curves of the propensity score-matched cohort showed that the overall survival (OS), but not the progression-free survival (PFS), was significantly longer in patients receiving statin therapy. However, a Cox regression analysis in the propensity score-matched cohort revealed that statin therapy was not an independent favorable prognostic factor, although it tended to be correlated with a favorable outcome. CONCLUSIONS: Statin therapy may be a combination tool for cancer immunotherapy in patients with NSCLC. These findings should be validated in further prospective studies with larger sample sizes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-022-09385-8. |
format | Online Article Text |
id | pubmed-9074359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-90743592022-05-07 A propensity score-matched analysis of the impact of statin therapy on the outcomes of patients with non-small-cell lung cancer receiving anti-PD-1 monotherapy: a multicenter retrospective study Takada, Kazuki Shimokawa, Mototsugu Takamori, Shinkichi Shimamatsu, Shinichiro Hirai, Fumihiko Tagawa, Tetsuzo Okamoto, Tatsuro Hamatake, Motoharu Tsuchiya-Kawano, Yuko Otsubo, Kohei Inoue, Koji Yoneshima, Yasuto Tanaka, Kentaro Okamoto, Isamu Nakanishi, Yoichi Mori, Masaki BMC Cancer Research Article BACKGROUND: Many studies have recently reported the association of concomitant medications with the response and survival in patients with non-small-cell lung cancer (NSCLC) treated with cancer immunotherapy. However, the clinical impact of statin therapy on the outcome of cancer immunotherapy in patients with NSCLC is poorly understood. METHODS: In our database, we retrospectively identified and enrolled 390 patients with advanced or recurrent NSCLC who were treated with anti-programmed cell death-1 (PD-1) monotherapy in clinical practice between January 2016 and December 2019 at 3 medical centers in Japan to examine the clinical impact of statin therapy on the survival of patients with NSCLC receiving anti-PD-1 monotherapy. A propensity score-matched analysis was conducted to minimize the bias arising from the patients’ backgrounds. RESULTS: The Kaplan–Meier curves of the propensity score-matched cohort showed that the overall survival (OS), but not the progression-free survival (PFS), was significantly longer in patients receiving statin therapy. However, a Cox regression analysis in the propensity score-matched cohort revealed that statin therapy was not an independent favorable prognostic factor, although it tended to be correlated with a favorable outcome. CONCLUSIONS: Statin therapy may be a combination tool for cancer immunotherapy in patients with NSCLC. These findings should be validated in further prospective studies with larger sample sizes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-022-09385-8. BioMed Central 2022-05-06 /pmc/articles/PMC9074359/ /pubmed/35524214 http://dx.doi.org/10.1186/s12885-022-09385-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Takada, Kazuki Shimokawa, Mototsugu Takamori, Shinkichi Shimamatsu, Shinichiro Hirai, Fumihiko Tagawa, Tetsuzo Okamoto, Tatsuro Hamatake, Motoharu Tsuchiya-Kawano, Yuko Otsubo, Kohei Inoue, Koji Yoneshima, Yasuto Tanaka, Kentaro Okamoto, Isamu Nakanishi, Yoichi Mori, Masaki A propensity score-matched analysis of the impact of statin therapy on the outcomes of patients with non-small-cell lung cancer receiving anti-PD-1 monotherapy: a multicenter retrospective study |
title | A propensity score-matched analysis of the impact of statin therapy on the outcomes of patients with non-small-cell lung cancer receiving anti-PD-1 monotherapy: a multicenter retrospective study |
title_full | A propensity score-matched analysis of the impact of statin therapy on the outcomes of patients with non-small-cell lung cancer receiving anti-PD-1 monotherapy: a multicenter retrospective study |
title_fullStr | A propensity score-matched analysis of the impact of statin therapy on the outcomes of patients with non-small-cell lung cancer receiving anti-PD-1 monotherapy: a multicenter retrospective study |
title_full_unstemmed | A propensity score-matched analysis of the impact of statin therapy on the outcomes of patients with non-small-cell lung cancer receiving anti-PD-1 monotherapy: a multicenter retrospective study |
title_short | A propensity score-matched analysis of the impact of statin therapy on the outcomes of patients with non-small-cell lung cancer receiving anti-PD-1 monotherapy: a multicenter retrospective study |
title_sort | propensity score-matched analysis of the impact of statin therapy on the outcomes of patients with non-small-cell lung cancer receiving anti-pd-1 monotherapy: a multicenter retrospective study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074359/ https://www.ncbi.nlm.nih.gov/pubmed/35524214 http://dx.doi.org/10.1186/s12885-022-09385-8 |
work_keys_str_mv | AT takadakazuki apropensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT shimokawamototsugu apropensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT takamorishinkichi apropensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT shimamatsushinichiro apropensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT hiraifumihiko apropensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT tagawatetsuzo apropensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT okamototatsuro apropensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT hamatakemotoharu apropensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT tsuchiyakawanoyuko apropensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT otsubokohei apropensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT inouekoji apropensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT yoneshimayasuto apropensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT tanakakentaro apropensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT okamotoisamu apropensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT nakanishiyoichi apropensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT morimasaki apropensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT takadakazuki propensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT shimokawamototsugu propensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT takamorishinkichi propensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT shimamatsushinichiro propensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT hiraifumihiko propensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT tagawatetsuzo propensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT okamototatsuro propensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT hamatakemotoharu propensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT tsuchiyakawanoyuko propensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT otsubokohei propensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT inouekoji propensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT yoneshimayasuto propensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT tanakakentaro propensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT okamotoisamu propensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT nakanishiyoichi propensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy AT morimasaki propensityscorematchedanalysisoftheimpactofstatintherapyontheoutcomesofpatientswithnonsmallcelllungcancerreceivingantipd1monotherapyamulticenterretrospectivestudy |