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Discovery of dihydrooxazolo[2,3-a]isoquinoliniums as highly specific inhibitors of hCE2

Human carboxylesterase 2 (hCE2) is one of the most abundant esterases distributed in human small intestine and colon, which participates in the hydrolysis of a variety of ester-bearing drugs and thereby affects the efficacy of these drugs. Herein, a new compound (23o) with a novel skeleton of dihydr...

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Detalles Bibliográficos
Autores principales:	Ding, Lixia, Wang, Lu, Zou, Kun, Li, Bo, Song, Yunqing, Zhang, Qihua, Zhao, Yitian, Xu, Zhijian, Ge, Guangbo, Zhao, Bo, Zhu, Weiliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074662/ https://www.ncbi.nlm.nih.gov/pubmed/35528066 http://dx.doi.org/10.1039/c9ra07457k

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