Advances in targeting and heterologous expression of genes involved in the synthesis of fungal secondary metabolites

The revolutionary discovery of penicillin only marks the start of our exploration for valuable fungal natural products. Advanced genome sequencing technologies have translated the fungal genome into a huge reservoir of “recipes” – biosynthetic gene clusters (BGCs) – for biosynthesis. Studying comple...

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Detalles Bibliográficos
Autores principales: Qiao, Yun-Ming, Yu, Rui-Lin, Zhu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074735/
https://www.ncbi.nlm.nih.gov/pubmed/35530690
http://dx.doi.org/10.1039/c9ra06908a
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author Qiao, Yun-Ming
Yu, Rui-Lin
Zhu, Ping
author_facet Qiao, Yun-Ming
Yu, Rui-Lin
Zhu, Ping
author_sort Qiao, Yun-Ming
collection PubMed
description The revolutionary discovery of penicillin only marks the start of our exploration for valuable fungal natural products. Advanced genome sequencing technologies have translated the fungal genome into a huge reservoir of “recipes” – biosynthetic gene clusters (BGCs) – for biosynthesis. Studying complex fungal genetics demands specific gene manipulation strategies. This review summarizes the current progress in efficient gene targeting in fungal cells and heterologous expression systems for expressing fungal BGCs of fungal secondary metabolites.
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spelling pubmed-90747352022-05-06 Advances in targeting and heterologous expression of genes involved in the synthesis of fungal secondary metabolites Qiao, Yun-Ming Yu, Rui-Lin Zhu, Ping RSC Adv Chemistry The revolutionary discovery of penicillin only marks the start of our exploration for valuable fungal natural products. Advanced genome sequencing technologies have translated the fungal genome into a huge reservoir of “recipes” – biosynthetic gene clusters (BGCs) – for biosynthesis. Studying complex fungal genetics demands specific gene manipulation strategies. This review summarizes the current progress in efficient gene targeting in fungal cells and heterologous expression systems for expressing fungal BGCs of fungal secondary metabolites. The Royal Society of Chemistry 2019-10-30 /pmc/articles/PMC9074735/ /pubmed/35530690 http://dx.doi.org/10.1039/c9ra06908a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Qiao, Yun-Ming
Yu, Rui-Lin
Zhu, Ping
Advances in targeting and heterologous expression of genes involved in the synthesis of fungal secondary metabolites
title Advances in targeting and heterologous expression of genes involved in the synthesis of fungal secondary metabolites
title_full Advances in targeting and heterologous expression of genes involved in the synthesis of fungal secondary metabolites
title_fullStr Advances in targeting and heterologous expression of genes involved in the synthesis of fungal secondary metabolites
title_full_unstemmed Advances in targeting and heterologous expression of genes involved in the synthesis of fungal secondary metabolites
title_short Advances in targeting and heterologous expression of genes involved in the synthesis of fungal secondary metabolites
title_sort advances in targeting and heterologous expression of genes involved in the synthesis of fungal secondary metabolites
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074735/
https://www.ncbi.nlm.nih.gov/pubmed/35530690
http://dx.doi.org/10.1039/c9ra06908a
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AT yuruilin advancesintargetingandheterologousexpressionofgenesinvolvedinthesynthesisoffungalsecondarymetabolites
AT zhuping advancesintargetingandheterologousexpressionofgenesinvolvedinthesynthesisoffungalsecondarymetabolites

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