Fragile X Mental Retardation Protein Mediates the Effects of Androgen on Hippocampal PSD95 Expression and Dendritic Spines Density/Morphology and Autism-Like Behaviors Through miR-125a

Dysregulated synaptic plasticity is a key feature of neurodevelopmental disorders, including autism. This study investigated whether Fragile X mental retardation protein (FMRP), a selective RNA-binding protein that regulates synaptic protein expression by interacting with miRNAs, mediates the effect...

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Detalles Bibliográficos
Autores principales: Chen, Huan, Qiao, Dan, Wang, Chang, Zhang, Bohan, Wang, Zhao, Tang, Longmei, Wang, Yibo, Zhang, Ran, Zhang, Yizhou, Song, Leigang, Zuo, Hongchun, Guo, Fangzhen, Wang, Xia, Li, Sha, Cui, Huixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074813/
https://www.ncbi.nlm.nih.gov/pubmed/35530178
http://dx.doi.org/10.3389/fncel.2022.872347

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