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Reducing Pain in Experimental Models of Intestinal Inflammation Affects the Immune Response
The incidence of inflammatory bowel disease with its two main manifestations, colitis ulcerosa and Crohn’s disease, is rising globally year after year. There is still a tremendous need to study the underlying pathomechanisms and a well-established tool in order to better understand the disease are c...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074866/ https://www.ncbi.nlm.nih.gov/pubmed/34871378 http://dx.doi.org/10.1093/ibd/izab290 |
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author | Golusda, Laura Kühl, Anja A Siegmund, Britta Paclik, Daniela |
author_facet | Golusda, Laura Kühl, Anja A Siegmund, Britta Paclik, Daniela |
author_sort | Golusda, Laura |
collection | PubMed |
description | The incidence of inflammatory bowel disease with its two main manifestations, colitis ulcerosa and Crohn’s disease, is rising globally year after year. There is still a tremendous need to study the underlying pathomechanisms and a well-established tool in order to better understand the disease are colitis models in rodents. Since the concept of the 3Rs was proposed by Russell and Burch, this would include pain medication in animal models of intestinal inflammation as a reduction of suffering. This review argues against pain medication because the administration of pain medication in its current form has an impact on the inflammatory process and the immune response, thus falsifying the results and the reproducibility and therefore leading to misconceptions. |
format | Online Article Text |
id | pubmed-9074866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-90748662022-05-09 Reducing Pain in Experimental Models of Intestinal Inflammation Affects the Immune Response Golusda, Laura Kühl, Anja A Siegmund, Britta Paclik, Daniela Inflamm Bowel Dis Basic Science Review The incidence of inflammatory bowel disease with its two main manifestations, colitis ulcerosa and Crohn’s disease, is rising globally year after year. There is still a tremendous need to study the underlying pathomechanisms and a well-established tool in order to better understand the disease are colitis models in rodents. Since the concept of the 3Rs was proposed by Russell and Burch, this would include pain medication in animal models of intestinal inflammation as a reduction of suffering. This review argues against pain medication because the administration of pain medication in its current form has an impact on the inflammatory process and the immune response, thus falsifying the results and the reproducibility and therefore leading to misconceptions. Oxford University Press 2021-12-06 /pmc/articles/PMC9074866/ /pubmed/34871378 http://dx.doi.org/10.1093/ibd/izab290 Text en © 2021 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Basic Science Review Golusda, Laura Kühl, Anja A Siegmund, Britta Paclik, Daniela Reducing Pain in Experimental Models of Intestinal Inflammation Affects the Immune Response |
title | Reducing Pain in Experimental Models of Intestinal Inflammation Affects the Immune Response |
title_full | Reducing Pain in Experimental Models of Intestinal Inflammation Affects the Immune Response |
title_fullStr | Reducing Pain in Experimental Models of Intestinal Inflammation Affects the Immune Response |
title_full_unstemmed | Reducing Pain in Experimental Models of Intestinal Inflammation Affects the Immune Response |
title_short | Reducing Pain in Experimental Models of Intestinal Inflammation Affects the Immune Response |
title_sort | reducing pain in experimental models of intestinal inflammation affects the immune response |
topic | Basic Science Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074866/ https://www.ncbi.nlm.nih.gov/pubmed/34871378 http://dx.doi.org/10.1093/ibd/izab290 |
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