Cargando…

Reducing Pain in Experimental Models of Intestinal Inflammation Affects the Immune Response

The incidence of inflammatory bowel disease with its two main manifestations, colitis ulcerosa and Crohn’s disease, is rising globally year after year. There is still a tremendous need to study the underlying pathomechanisms and a well-established tool in order to better understand the disease are c...

Descripción completa

Detalles Bibliográficos
Autores principales: Golusda, Laura, Kühl, Anja A, Siegmund, Britta, Paclik, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074866/
https://www.ncbi.nlm.nih.gov/pubmed/34871378
http://dx.doi.org/10.1093/ibd/izab290
_version_ 1784701556186152960
author Golusda, Laura
Kühl, Anja A
Siegmund, Britta
Paclik, Daniela
author_facet Golusda, Laura
Kühl, Anja A
Siegmund, Britta
Paclik, Daniela
author_sort Golusda, Laura
collection PubMed
description The incidence of inflammatory bowel disease with its two main manifestations, colitis ulcerosa and Crohn’s disease, is rising globally year after year. There is still a tremendous need to study the underlying pathomechanisms and a well-established tool in order to better understand the disease are colitis models in rodents. Since the concept of the 3Rs was proposed by Russell and Burch, this would include pain medication in animal models of intestinal inflammation as a reduction of suffering. This review argues against pain medication because the administration of pain medication in its current form has an impact on the inflammatory process and the immune response, thus falsifying the results and the reproducibility and therefore leading to misconceptions.
format Online
Article
Text
id pubmed-9074866
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-90748662022-05-09 Reducing Pain in Experimental Models of Intestinal Inflammation Affects the Immune Response Golusda, Laura Kühl, Anja A Siegmund, Britta Paclik, Daniela Inflamm Bowel Dis Basic Science Review The incidence of inflammatory bowel disease with its two main manifestations, colitis ulcerosa and Crohn’s disease, is rising globally year after year. There is still a tremendous need to study the underlying pathomechanisms and a well-established tool in order to better understand the disease are colitis models in rodents. Since the concept of the 3Rs was proposed by Russell and Burch, this would include pain medication in animal models of intestinal inflammation as a reduction of suffering. This review argues against pain medication because the administration of pain medication in its current form has an impact on the inflammatory process and the immune response, thus falsifying the results and the reproducibility and therefore leading to misconceptions. Oxford University Press 2021-12-06 /pmc/articles/PMC9074866/ /pubmed/34871378 http://dx.doi.org/10.1093/ibd/izab290 Text en © 2021 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Basic Science Review
Golusda, Laura
Kühl, Anja A
Siegmund, Britta
Paclik, Daniela
Reducing Pain in Experimental Models of Intestinal Inflammation Affects the Immune Response
title Reducing Pain in Experimental Models of Intestinal Inflammation Affects the Immune Response
title_full Reducing Pain in Experimental Models of Intestinal Inflammation Affects the Immune Response
title_fullStr Reducing Pain in Experimental Models of Intestinal Inflammation Affects the Immune Response
title_full_unstemmed Reducing Pain in Experimental Models of Intestinal Inflammation Affects the Immune Response
title_short Reducing Pain in Experimental Models of Intestinal Inflammation Affects the Immune Response
title_sort reducing pain in experimental models of intestinal inflammation affects the immune response
topic Basic Science Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074866/
https://www.ncbi.nlm.nih.gov/pubmed/34871378
http://dx.doi.org/10.1093/ibd/izab290
work_keys_str_mv AT golusdalaura reducingpaininexperimentalmodelsofintestinalinflammationaffectstheimmuneresponse
AT kuhlanjaa reducingpaininexperimentalmodelsofintestinalinflammationaffectstheimmuneresponse
AT siegmundbritta reducingpaininexperimentalmodelsofintestinalinflammationaffectstheimmuneresponse
AT paclikdaniela reducingpaininexperimentalmodelsofintestinalinflammationaffectstheimmuneresponse