Near-infrared-induced IR780-loaded PLGA nanoparticles for photothermal therapy to treat breast cancer metastasis in bones

Nanodrug-based cancer therapy, especially when treating bone metastases, faces the problem of limited therapeutic efficacy. In this work, we reported a photothermally triggered nanomaterial based on IR780-entrapped poly-lactide-co-glycolide (PLGA) nanoparticles (IR780@PLGA NPs) for the photothermal...

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Detalles Bibliográficos
Autores principales: Li, Jingyi, Hu, Huiyu, Jiang, Zichao, Chen, Sijie, Pan, Yixiao, Guo, Qi, Xing, Qiqi, Jing, Zhaocheng, Hu, Yihe, Wang, Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074936/
https://www.ncbi.nlm.nih.gov/pubmed/35540567
http://dx.doi.org/10.1039/c9ra05813c
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author Li, Jingyi
Hu, Huiyu
Jiang, Zichao
Chen, Sijie
Pan, Yixiao
Guo, Qi
Xing, Qiqi
Jing, Zhaocheng
Hu, Yihe
Wang, Long
author_facet Li, Jingyi
Hu, Huiyu
Jiang, Zichao
Chen, Sijie
Pan, Yixiao
Guo, Qi
Xing, Qiqi
Jing, Zhaocheng
Hu, Yihe
Wang, Long
author_sort Li, Jingyi
collection PubMed
description Nanodrug-based cancer therapy, especially when treating bone metastases, faces the problem of limited therapeutic efficacy. In this work, we reported a photothermally triggered nanomaterial based on IR780-entrapped poly-lactide-co-glycolide (PLGA) nanoparticles (IR780@PLGA NPs) for the photothermal therapy of bone metastases of breast cancer, in which IR780 converted light into heat to play a role in “burning” the tumors. Anti-tumor therapy studies showed the impressive effectiveness of IR780@PLGA NPs in the photothermal therapy (PTT) of bone metastases. As a result, the IR780@PLGA NPs show a great potential for controlling the bone metastases of breast cancer.
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spelling pubmed-90749362022-05-09 Near-infrared-induced IR780-loaded PLGA nanoparticles for photothermal therapy to treat breast cancer metastasis in bones Li, Jingyi Hu, Huiyu Jiang, Zichao Chen, Sijie Pan, Yixiao Guo, Qi Xing, Qiqi Jing, Zhaocheng Hu, Yihe Wang, Long RSC Adv Chemistry Nanodrug-based cancer therapy, especially when treating bone metastases, faces the problem of limited therapeutic efficacy. In this work, we reported a photothermally triggered nanomaterial based on IR780-entrapped poly-lactide-co-glycolide (PLGA) nanoparticles (IR780@PLGA NPs) for the photothermal therapy of bone metastases of breast cancer, in which IR780 converted light into heat to play a role in “burning” the tumors. Anti-tumor therapy studies showed the impressive effectiveness of IR780@PLGA NPs in the photothermal therapy (PTT) of bone metastases. As a result, the IR780@PLGA NPs show a great potential for controlling the bone metastases of breast cancer. The Royal Society of Chemistry 2019-11-05 /pmc/articles/PMC9074936/ /pubmed/35540567 http://dx.doi.org/10.1039/c9ra05813c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Li, Jingyi
Hu, Huiyu
Jiang, Zichao
Chen, Sijie
Pan, Yixiao
Guo, Qi
Xing, Qiqi
Jing, Zhaocheng
Hu, Yihe
Wang, Long
Near-infrared-induced IR780-loaded PLGA nanoparticles for photothermal therapy to treat breast cancer metastasis in bones
title Near-infrared-induced IR780-loaded PLGA nanoparticles for photothermal therapy to treat breast cancer metastasis in bones
title_full Near-infrared-induced IR780-loaded PLGA nanoparticles for photothermal therapy to treat breast cancer metastasis in bones
title_fullStr Near-infrared-induced IR780-loaded PLGA nanoparticles for photothermal therapy to treat breast cancer metastasis in bones
title_full_unstemmed Near-infrared-induced IR780-loaded PLGA nanoparticles for photothermal therapy to treat breast cancer metastasis in bones
title_short Near-infrared-induced IR780-loaded PLGA nanoparticles for photothermal therapy to treat breast cancer metastasis in bones
title_sort near-infrared-induced ir780-loaded plga nanoparticles for photothermal therapy to treat breast cancer metastasis in bones
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074936/
https://www.ncbi.nlm.nih.gov/pubmed/35540567
http://dx.doi.org/10.1039/c9ra05813c
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