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Blue light photoredox-catalysed acetalation of alkynyl bromides

Herein, we report an organo-photoredox-based protocol using 2,2-diethoxyacetic acid as the acetal source to achieve acetalation of alkynyl bromides to afford various alkynyl acetal products. In addition to arylethynyl bromides, substrates bearing heteroaryl rings (thiophene, pyridine, and indole) sm...

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Autores principales: Lyu, Xue-Li, Huang, Shi-Sheng, Song, Hong-Jian, Liu, Yu-Xiu, Wang, Qing-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074944/
https://www.ncbi.nlm.nih.gov/pubmed/35540617
http://dx.doi.org/10.1039/c9ra06596b
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author Lyu, Xue-Li
Huang, Shi-Sheng
Song, Hong-Jian
Liu, Yu-Xiu
Wang, Qing-Min
author_facet Lyu, Xue-Li
Huang, Shi-Sheng
Song, Hong-Jian
Liu, Yu-Xiu
Wang, Qing-Min
author_sort Lyu, Xue-Li
collection PubMed
description Herein, we report an organo-photoredox-based protocol using 2,2-diethoxyacetic acid as the acetal source to achieve acetalation of alkynyl bromides to afford various alkynyl acetal products. In addition to arylethynyl bromides, substrates bearing heteroaryl rings (thiophene, pyridine, and indole) smoothly gave the corresponding acetalation products. This mild protocol has potential utility for the synthesis of aldehydes by further protonization.
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spelling pubmed-90749442022-05-09 Blue light photoredox-catalysed acetalation of alkynyl bromides Lyu, Xue-Li Huang, Shi-Sheng Song, Hong-Jian Liu, Yu-Xiu Wang, Qing-Min RSC Adv Chemistry Herein, we report an organo-photoredox-based protocol using 2,2-diethoxyacetic acid as the acetal source to achieve acetalation of alkynyl bromides to afford various alkynyl acetal products. In addition to arylethynyl bromides, substrates bearing heteroaryl rings (thiophene, pyridine, and indole) smoothly gave the corresponding acetalation products. This mild protocol has potential utility for the synthesis of aldehydes by further protonization. The Royal Society of Chemistry 2019-11-06 /pmc/articles/PMC9074944/ /pubmed/35540617 http://dx.doi.org/10.1039/c9ra06596b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Lyu, Xue-Li
Huang, Shi-Sheng
Song, Hong-Jian
Liu, Yu-Xiu
Wang, Qing-Min
Blue light photoredox-catalysed acetalation of alkynyl bromides
title Blue light photoredox-catalysed acetalation of alkynyl bromides
title_full Blue light photoredox-catalysed acetalation of alkynyl bromides
title_fullStr Blue light photoredox-catalysed acetalation of alkynyl bromides
title_full_unstemmed Blue light photoredox-catalysed acetalation of alkynyl bromides
title_short Blue light photoredox-catalysed acetalation of alkynyl bromides
title_sort blue light photoredox-catalysed acetalation of alkynyl bromides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074944/
https://www.ncbi.nlm.nih.gov/pubmed/35540617
http://dx.doi.org/10.1039/c9ra06596b
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