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Blue light photoredox-catalysed acetalation of alkynyl bromides
Herein, we report an organo-photoredox-based protocol using 2,2-diethoxyacetic acid as the acetal source to achieve acetalation of alkynyl bromides to afford various alkynyl acetal products. In addition to arylethynyl bromides, substrates bearing heteroaryl rings (thiophene, pyridine, and indole) sm...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074944/ https://www.ncbi.nlm.nih.gov/pubmed/35540617 http://dx.doi.org/10.1039/c9ra06596b |
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author | Lyu, Xue-Li Huang, Shi-Sheng Song, Hong-Jian Liu, Yu-Xiu Wang, Qing-Min |
author_facet | Lyu, Xue-Li Huang, Shi-Sheng Song, Hong-Jian Liu, Yu-Xiu Wang, Qing-Min |
author_sort | Lyu, Xue-Li |
collection | PubMed |
description | Herein, we report an organo-photoredox-based protocol using 2,2-diethoxyacetic acid as the acetal source to achieve acetalation of alkynyl bromides to afford various alkynyl acetal products. In addition to arylethynyl bromides, substrates bearing heteroaryl rings (thiophene, pyridine, and indole) smoothly gave the corresponding acetalation products. This mild protocol has potential utility for the synthesis of aldehydes by further protonization. |
format | Online Article Text |
id | pubmed-9074944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90749442022-05-09 Blue light photoredox-catalysed acetalation of alkynyl bromides Lyu, Xue-Li Huang, Shi-Sheng Song, Hong-Jian Liu, Yu-Xiu Wang, Qing-Min RSC Adv Chemistry Herein, we report an organo-photoredox-based protocol using 2,2-diethoxyacetic acid as the acetal source to achieve acetalation of alkynyl bromides to afford various alkynyl acetal products. In addition to arylethynyl bromides, substrates bearing heteroaryl rings (thiophene, pyridine, and indole) smoothly gave the corresponding acetalation products. This mild protocol has potential utility for the synthesis of aldehydes by further protonization. The Royal Society of Chemistry 2019-11-06 /pmc/articles/PMC9074944/ /pubmed/35540617 http://dx.doi.org/10.1039/c9ra06596b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Lyu, Xue-Li Huang, Shi-Sheng Song, Hong-Jian Liu, Yu-Xiu Wang, Qing-Min Blue light photoredox-catalysed acetalation of alkynyl bromides |
title | Blue light photoredox-catalysed acetalation of alkynyl bromides |
title_full | Blue light photoredox-catalysed acetalation of alkynyl bromides |
title_fullStr | Blue light photoredox-catalysed acetalation of alkynyl bromides |
title_full_unstemmed | Blue light photoredox-catalysed acetalation of alkynyl bromides |
title_short | Blue light photoredox-catalysed acetalation of alkynyl bromides |
title_sort | blue light photoredox-catalysed acetalation of alkynyl bromides |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074944/ https://www.ncbi.nlm.nih.gov/pubmed/35540617 http://dx.doi.org/10.1039/c9ra06596b |
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