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PGC-1α deficiency reveals sex-specific links between cardiac energy metabolism and EC-coupling during development of heart failure in mice

AIMS: Biological sex has fundamental effects on mammalian heart physiology and pathogenesis. While it has been established that female sex is a protective factor against most cardiovascular diseases (CVDs), this beneficial effect may involve pathways associated with cardiac energy metabolism. Our ai...

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Detalles Bibliográficos
Autores principales: Naumenko, Nikolay, Mutikainen, Maija, Holappa, Lari, Ruas, Jorge L, Tuomainen, Tomi, Tavi, Pasi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074965/
https://www.ncbi.nlm.nih.gov/pubmed/34086875
http://dx.doi.org/10.1093/cvr/cvab188