CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors

AIMS: Guanylyl cyclase-B (GC-B; natriuretic peptide receptor-B, NPR-B) stimulation by C-type natriuretic peptide (CNP) increases cGMP and causes a lusitropic and negative inotropic response in adult myocardium. These effects are not mimicked by NPR-A (GC-A) stimulation by brain natriuretic peptide (...

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Detalles Bibliográficos
Autores principales: Manfra, Ornella, Calamera, Gaia, Froese, Alexander, Arunthavarajah, Dulasi, Surdo, Nicoletta C, Meier, Silja, Melleby, Arne Olav, Aasrum, Monica, Aronsen, Jan Magnus, Nikolaev, Viacheslav O, Zaccolo, Manuela, Moltzau, Lise Román, Levy, Finn Olav, Andressen, Kjetil Wessel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074987/
https://www.ncbi.nlm.nih.gov/pubmed/33970224
http://dx.doi.org/10.1093/cvr/cvab167

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