Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca(2+) cycling

AIMS: Autophagy protects against the development of cardiac hypertrophy and failure. While aberrant Ca(2+) handling promotes myocardial remodelling and contributes to contractile dysfunction, the role of autophagy in maintaining Ca(2+) homeostasis remains elusive. Here, we examined whether Atg5 defi...

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Detalles Bibliográficos
Autores principales: Ljubojević-Holzer, Senka, Kraler, Simon, Djalinac, Nataša, Abdellatif, Mahmoud, Voglhuber, Julia, Schipke, Julia, Schmidt, Marlene, Kling, Katharina-Maria, Franke, Greta Therese, Herbst, Viktoria, Zirlik, Andreas, von Lewinski, Dirk, Scherr, Daniel, Rainer, Peter P, Kohlhaas, Michael, Nickel, Alexander, Mühlfeld, Christian, Maack, Christoph, Sedej, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074988/
https://www.ncbi.nlm.nih.gov/pubmed/33752242
http://dx.doi.org/10.1093/cvr/cvab112

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