Consider Myocarditis When Patients Treated with Immune Checkpoint Inhibitors Present with Ocular Symptoms

Immune checkpoint inhibitors (ICIs) have been associated with neurological immune related adverse events (irAE-N) and patients with ICI toxicity may present with neurological or ocular symptoms. Furthermore, patients on ICI may initially present to oncology or neurology. We report a case series of 3...

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Detalles Bibliográficos
Autores principales: Rhee, John Y, Torun, Nurhan, Neilan, Tomas G, Guidon, Amanda C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074998/
https://www.ncbi.nlm.nih.gov/pubmed/35348772
http://dx.doi.org/10.1093/oncolo/oyac033
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author Rhee, John Y
Torun, Nurhan
Neilan, Tomas G
Guidon, Amanda C
author_facet Rhee, John Y
Torun, Nurhan
Neilan, Tomas G
Guidon, Amanda C
author_sort Rhee, John Y
collection PubMed
description Immune checkpoint inhibitors (ICIs) have been associated with neurological immune related adverse events (irAE-N) and patients with ICI toxicity may present with neurological or ocular symptoms. Furthermore, patients on ICI may initially present to oncology or neurology. We report a case series of 3 patients treated with ICIs presenting with diplopia or ptosis, found to have concurrent myocarditis in addition to immune-related myopathy (irMyopathy) or myasthenia gravis (irMG). None of the patients described cardiac symptoms, underscoring the importance of screening for myocarditis in patients presenting with diplopia and/or other neuromuscular symptoms which may suggest either irMyopathy or irMG.
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spelling pubmed-90749982022-05-09 Consider Myocarditis When Patients Treated with Immune Checkpoint Inhibitors Present with Ocular Symptoms Rhee, John Y Torun, Nurhan Neilan, Tomas G Guidon, Amanda C Oncologist Brief Communication Immune checkpoint inhibitors (ICIs) have been associated with neurological immune related adverse events (irAE-N) and patients with ICI toxicity may present with neurological or ocular symptoms. Furthermore, patients on ICI may initially present to oncology or neurology. We report a case series of 3 patients treated with ICIs presenting with diplopia or ptosis, found to have concurrent myocarditis in addition to immune-related myopathy (irMyopathy) or myasthenia gravis (irMG). None of the patients described cardiac symptoms, underscoring the importance of screening for myocarditis in patients presenting with diplopia and/or other neuromuscular symptoms which may suggest either irMyopathy or irMG. Oxford University Press 2022-03-28 /pmc/articles/PMC9074998/ /pubmed/35348772 http://dx.doi.org/10.1093/oncolo/oyac033 Text en © The Author(s) 2022. Published by Oxford University Press. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Communication
Rhee, John Y
Torun, Nurhan
Neilan, Tomas G
Guidon, Amanda C
Consider Myocarditis When Patients Treated with Immune Checkpoint Inhibitors Present with Ocular Symptoms
title Consider Myocarditis When Patients Treated with Immune Checkpoint Inhibitors Present with Ocular Symptoms
title_full Consider Myocarditis When Patients Treated with Immune Checkpoint Inhibitors Present with Ocular Symptoms
title_fullStr Consider Myocarditis When Patients Treated with Immune Checkpoint Inhibitors Present with Ocular Symptoms
title_full_unstemmed Consider Myocarditis When Patients Treated with Immune Checkpoint Inhibitors Present with Ocular Symptoms
title_short Consider Myocarditis When Patients Treated with Immune Checkpoint Inhibitors Present with Ocular Symptoms
title_sort consider myocarditis when patients treated with immune checkpoint inhibitors present with ocular symptoms
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9074998/
https://www.ncbi.nlm.nih.gov/pubmed/35348772
http://dx.doi.org/10.1093/oncolo/oyac033
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