Linear PVA–DTPA–Gd conjugate for magnetic resonance imaging

In this study, we report the preparation and characterization of the PVA–DTPA–Gd conjugate as a potential MRI contrast agent (CA). The r(1) value and the r(2)/r(1) ratio were about 5.6 mM(−1) s(−1) and 1.31, respectively. In vitro toxicity studies not only demonstrated that the polymeric system poss...

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Detalles Bibliográficos
Autores principales: Xu, Weibing, Lin, Zhiyan, Li, Guichen, Long, Haitao, Du, Mingyuan, Fu, Guorui, Pu, Lumei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075117/
https://www.ncbi.nlm.nih.gov/pubmed/35539082
http://dx.doi.org/10.1039/c9ra05607f
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author Xu, Weibing
Lin, Zhiyan
Li, Guichen
Long, Haitao
Du, Mingyuan
Fu, Guorui
Pu, Lumei
author_facet Xu, Weibing
Lin, Zhiyan
Li, Guichen
Long, Haitao
Du, Mingyuan
Fu, Guorui
Pu, Lumei
author_sort Xu, Weibing
collection PubMed
description In this study, we report the preparation and characterization of the PVA–DTPA–Gd conjugate as a potential MRI contrast agent (CA). The r(1) value and the r(2)/r(1) ratio were about 5.6 mM(−1) s(−1) and 1.31, respectively. In vitro toxicity studies not only demonstrated that the polymeric system possessed good biocompatibility, but also proved that the conjugate could be an attractive candidate for CA.
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spelling pubmed-90751172022-05-09 Linear PVA–DTPA–Gd conjugate for magnetic resonance imaging Xu, Weibing Lin, Zhiyan Li, Guichen Long, Haitao Du, Mingyuan Fu, Guorui Pu, Lumei RSC Adv Chemistry In this study, we report the preparation and characterization of the PVA–DTPA–Gd conjugate as a potential MRI contrast agent (CA). The r(1) value and the r(2)/r(1) ratio were about 5.6 mM(−1) s(−1) and 1.31, respectively. In vitro toxicity studies not only demonstrated that the polymeric system possessed good biocompatibility, but also proved that the conjugate could be an attractive candidate for CA. The Royal Society of Chemistry 2019-11-12 /pmc/articles/PMC9075117/ /pubmed/35539082 http://dx.doi.org/10.1039/c9ra05607f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Xu, Weibing
Lin, Zhiyan
Li, Guichen
Long, Haitao
Du, Mingyuan
Fu, Guorui
Pu, Lumei
Linear PVA–DTPA–Gd conjugate for magnetic resonance imaging
title Linear PVA–DTPA–Gd conjugate for magnetic resonance imaging
title_full Linear PVA–DTPA–Gd conjugate for magnetic resonance imaging
title_fullStr Linear PVA–DTPA–Gd conjugate for magnetic resonance imaging
title_full_unstemmed Linear PVA–DTPA–Gd conjugate for magnetic resonance imaging
title_short Linear PVA–DTPA–Gd conjugate for magnetic resonance imaging
title_sort linear pva–dtpa–gd conjugate for magnetic resonance imaging
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075117/
https://www.ncbi.nlm.nih.gov/pubmed/35539082
http://dx.doi.org/10.1039/c9ra05607f
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AT dumingyuan linearpvadtpagdconjugateformagneticresonanceimaging
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