Cargando…

Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates

BACKGROUND: Because of discrepancies between donor supply and recipient demand, the cardiac transplantation process aims to prioritize the most medically urgent patients. It remains unknown how recipients with the lowest medical urgency compare to others in the allocation process. We aimed to examin...

Descripción completa

Detalles Bibliográficos
Autores principales: Fuery, Michael A., Chouairi, Fouad, Natov, Peter, Bhinder, Jasjit, Rose Chiravuri, Maya, Wilson, Lynn, Clark, Katherine A., Reinhardt, Samuel W., Mullan, Clancy, Miller, P. Elliott, Davis, Robert P., Rogers, Joseph G., Patel, Chetan B., Sen, Sounok, Geirsson, Arnar, Anwer, Muhammad, Desai, Nihar, Ahmad, Tariq
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075266/
https://www.ncbi.nlm.nih.gov/pubmed/34743559
http://dx.doi.org/10.1161/JAHA.121.023662
_version_ 1784701644046336000
author Fuery, Michael A.
Chouairi, Fouad
Natov, Peter
Bhinder, Jasjit
Rose Chiravuri, Maya
Wilson, Lynn
Clark, Katherine A.
Reinhardt, Samuel W.
Mullan, Clancy
Miller, P. Elliott
Davis, Robert P.
Rogers, Joseph G.
Patel, Chetan B.
Sen, Sounok
Geirsson, Arnar
Anwer, Muhammad
Desai, Nihar
Ahmad, Tariq
author_facet Fuery, Michael A.
Chouairi, Fouad
Natov, Peter
Bhinder, Jasjit
Rose Chiravuri, Maya
Wilson, Lynn
Clark, Katherine A.
Reinhardt, Samuel W.
Mullan, Clancy
Miller, P. Elliott
Davis, Robert P.
Rogers, Joseph G.
Patel, Chetan B.
Sen, Sounok
Geirsson, Arnar
Anwer, Muhammad
Desai, Nihar
Ahmad, Tariq
author_sort Fuery, Michael A.
collection PubMed
description BACKGROUND: Because of discrepancies between donor supply and recipient demand, the cardiac transplantation process aims to prioritize the most medically urgent patients. It remains unknown how recipients with the lowest medical urgency compare to others in the allocation process. We aimed to examine differences in clinical characteristics, organ allocation patterns, and outcomes between cardiac transplantation candidates with the lowest and highest medical urgency. METHODS AND RESULTS: We performed a retrospective analysis of the United Network for Organ Sharing database. Patients listed for cardiac transplantation between January 2011 and May 2020 were stratified according to status at time of transplantation. Baseline recipient and donor characteristics, waitlist survival, and posttransplantation outcomes were compared in the years before and after the 2018 allocation system change. Lower urgency patients in the old system were older (58.5 versus 56 years) and more likely female (54.4% versus 23.8%) compared with the highest urgency patients, and these trends persisted in the new system (P<0.001, all). Donors for the lowest urgency patients were more likely older, female, or have a history of cytomegalovirus, hepatitis C, or diabetes (P<0.01, all). The lowest urgency patients had longer waitlist times and under the new allocation system received organs from shorter distances with decreased ischemic times (178 miles versus 269 miles, 3.1 versus 3.5 hours; P<0.001, all). There was no difference in posttransplantation survival (P<0.01, all). CONCLUSIONS: Patients transplanted as lower urgency receive hearts from donors with additional comorbidities compared with higher urgency patients, but outcomes are similar at 1 year.
format Online
Article
Text
id pubmed-9075266
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-90752662022-05-10 Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates Fuery, Michael A. Chouairi, Fouad Natov, Peter Bhinder, Jasjit Rose Chiravuri, Maya Wilson, Lynn Clark, Katherine A. Reinhardt, Samuel W. Mullan, Clancy Miller, P. Elliott Davis, Robert P. Rogers, Joseph G. Patel, Chetan B. Sen, Sounok Geirsson, Arnar Anwer, Muhammad Desai, Nihar Ahmad, Tariq J Am Heart Assoc Original Research BACKGROUND: Because of discrepancies between donor supply and recipient demand, the cardiac transplantation process aims to prioritize the most medically urgent patients. It remains unknown how recipients with the lowest medical urgency compare to others in the allocation process. We aimed to examine differences in clinical characteristics, organ allocation patterns, and outcomes between cardiac transplantation candidates with the lowest and highest medical urgency. METHODS AND RESULTS: We performed a retrospective analysis of the United Network for Organ Sharing database. Patients listed for cardiac transplantation between January 2011 and May 2020 were stratified according to status at time of transplantation. Baseline recipient and donor characteristics, waitlist survival, and posttransplantation outcomes were compared in the years before and after the 2018 allocation system change. Lower urgency patients in the old system were older (58.5 versus 56 years) and more likely female (54.4% versus 23.8%) compared with the highest urgency patients, and these trends persisted in the new system (P<0.001, all). Donors for the lowest urgency patients were more likely older, female, or have a history of cytomegalovirus, hepatitis C, or diabetes (P<0.01, all). The lowest urgency patients had longer waitlist times and under the new allocation system received organs from shorter distances with decreased ischemic times (178 miles versus 269 miles, 3.1 versus 3.5 hours; P<0.001, all). There was no difference in posttransplantation survival (P<0.01, all). CONCLUSIONS: Patients transplanted as lower urgency receive hearts from donors with additional comorbidities compared with higher urgency patients, but outcomes are similar at 1 year. John Wiley and Sons Inc. 2021-11-07 /pmc/articles/PMC9075266/ /pubmed/34743559 http://dx.doi.org/10.1161/JAHA.121.023662 Text en © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Fuery, Michael A.
Chouairi, Fouad
Natov, Peter
Bhinder, Jasjit
Rose Chiravuri, Maya
Wilson, Lynn
Clark, Katherine A.
Reinhardt, Samuel W.
Mullan, Clancy
Miller, P. Elliott
Davis, Robert P.
Rogers, Joseph G.
Patel, Chetan B.
Sen, Sounok
Geirsson, Arnar
Anwer, Muhammad
Desai, Nihar
Ahmad, Tariq
Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates
title Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates
title_full Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates
title_fullStr Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates
title_full_unstemmed Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates
title_short Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates
title_sort trends and outcomes of cardiac transplantation in the lowest urgency candidates
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075266/
https://www.ncbi.nlm.nih.gov/pubmed/34743559
http://dx.doi.org/10.1161/JAHA.121.023662
work_keys_str_mv AT fuerymichaela trendsandoutcomesofcardiactransplantationinthelowesturgencycandidates
AT chouairifouad trendsandoutcomesofcardiactransplantationinthelowesturgencycandidates
AT natovpeter trendsandoutcomesofcardiactransplantationinthelowesturgencycandidates
AT bhinderjasjit trendsandoutcomesofcardiactransplantationinthelowesturgencycandidates
AT rosechiravurimaya trendsandoutcomesofcardiactransplantationinthelowesturgencycandidates
AT wilsonlynn trendsandoutcomesofcardiactransplantationinthelowesturgencycandidates
AT clarkkatherinea trendsandoutcomesofcardiactransplantationinthelowesturgencycandidates
AT reinhardtsamuelw trendsandoutcomesofcardiactransplantationinthelowesturgencycandidates
AT mullanclancy trendsandoutcomesofcardiactransplantationinthelowesturgencycandidates
AT millerpelliott trendsandoutcomesofcardiactransplantationinthelowesturgencycandidates
AT davisrobertp trendsandoutcomesofcardiactransplantationinthelowesturgencycandidates
AT rogersjosephg trendsandoutcomesofcardiactransplantationinthelowesturgencycandidates
AT patelchetanb trendsandoutcomesofcardiactransplantationinthelowesturgencycandidates
AT sensounok trendsandoutcomesofcardiactransplantationinthelowesturgencycandidates
AT geirssonarnar trendsandoutcomesofcardiactransplantationinthelowesturgencycandidates
AT anwermuhammad trendsandoutcomesofcardiactransplantationinthelowesturgencycandidates
AT desainihar trendsandoutcomesofcardiactransplantationinthelowesturgencycandidates
AT ahmadtariq trendsandoutcomesofcardiactransplantationinthelowesturgencycandidates