Haptoglobin Regulates Macrophage/Microglia‐Induced Inflammation and Prevents Ischemic Brain Damage Via Binding to HMGB1

BACKGROUND: HMGB1 (high‐mobility group box 1) is known to worsen the functional prognosis after cerebral ischemia. Hp (haptoglobin) binds and sequesters HMGB1. Furthermore, Hp‐HMGB1 complexes are rapidly cleared by scavenger receptors on macrophages/microglia and modulate polarization of macrophages...

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Detalles Bibliográficos
Autores principales: Morimoto, Mayuka, Nakano, Takafumi, Egashira, Saki, Irie, Keiichi, Matsuyama, Kiyoshi, Wada, Momoka, Nakamura, Yoshihiko, Shigemori, Yutaka, Ishikura, Hiroyasu, Yamashita, Yuta, Hayakawa, Kazuhide, Sano, Kazunori, Mishima, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075294/
https://www.ncbi.nlm.nih.gov/pubmed/35243897
http://dx.doi.org/10.1161/JAHA.121.024424

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