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Pregnane X Receptor‒4β‐Hydroxycholesterol Axis in the Regulation of Overweight‐ and Obesity‐Induced Hypertension

BACKGROUND: Mechanisms mediating hypertensive effects of overweight and obesity have not been fully elucidated. We showed previously that activation of pregnane X receptor (PXR) by rifampicin elevates 24‐hour blood pressure (BP) and plasma 4β‐hydroxycholesterol (4βHC), agonist for liver X receptor (...

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Detalles Bibliográficos
Autores principales:	Rahunen, Roosa, Kummu, Outi, Koivukangas, Vesa, Hautajärvi, Heidi, Hakkola, Jukka, Rysä, Jaana, Hukkanen, Janne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075316/ https://www.ncbi.nlm.nih.gov/pubmed/35229613 http://dx.doi.org/10.1161/JAHA.121.023492

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