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Causal Effect of Obstructive Sleep Apnea on Atrial Fibrillation: A Mendelian Randomization Study

BACKGROUND: Obstructive sleep apnea (OSA) has shown to be associated with an increased risk of atrial fibrillation in observational studies. Whether this association reflect causal effect is still unclear. The aim of this study was to evaluate the causal effect of OSA on atrial fibrillation. METHODS...

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Autores principales: Chen, Weiqi, Cai, Xueli, Yan, Hongyi, Pan, Yuesong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075405/
https://www.ncbi.nlm.nih.gov/pubmed/34796736
http://dx.doi.org/10.1161/JAHA.121.022560
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author Chen, Weiqi
Cai, Xueli
Yan, Hongyi
Pan, Yuesong
author_facet Chen, Weiqi
Cai, Xueli
Yan, Hongyi
Pan, Yuesong
author_sort Chen, Weiqi
collection PubMed
description BACKGROUND: Obstructive sleep apnea (OSA) has shown to be associated with an increased risk of atrial fibrillation in observational studies. Whether this association reflect causal effect is still unclear. The aim of this study was to evaluate the causal effect of OSA on atrial fibrillation. METHODS AND RESULTS: We used a 2‐sample Mendelian randomization (MR) method to evaluate the causal effect of OSA on atrial fibrillation. Summary data on genetic variant‐OSA association were obtained from a recently published genome‐wide association studies with up to 217 955 individuals and data on variant‐atrial fibrillation association from another genome‐wide association study with up to 1 030 836 individuals. Effect estimates were evaluated using inverse‐variance weighted method. Other MR analyses, including penalized inverse‐variance weighted, penalized robust inverse‐variance weighted, MR‐Egger, simple median, weighted median, weighted mode‐based estimate and Mendelian Randomization Pleiotropy Residual Sum and Outlier methods were performed in sensitivity analyses. The MR analyses in both the fixed‐effect and random‐effect inverse‐variance weighted models showed that genetically predicted OSA was associated with an increased risk of atrial fibrillation (odds ratio [OR], 1.21; 95% CI, 1.12–1.31, P<0.001; OR, 1.21; 95% CI, 1.11–1.32, P<0.001) using 5 single nucleotide polymorphisms as the instruments. MR‐Egger indicated no evidence of genetic pleiotropy (intercept, −0.014; 95% CI, −0.033 to 0.005, P=0.14). Results were robust using other MR methods in sensitivity analyses. CONCLUSIONS: This MR analysis found that genetically predicted OSA had causal effect on an increased risk of atrial fibrillation.
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spelling pubmed-90754052022-05-10 Causal Effect of Obstructive Sleep Apnea on Atrial Fibrillation: A Mendelian Randomization Study Chen, Weiqi Cai, Xueli Yan, Hongyi Pan, Yuesong J Am Heart Assoc Original Research BACKGROUND: Obstructive sleep apnea (OSA) has shown to be associated with an increased risk of atrial fibrillation in observational studies. Whether this association reflect causal effect is still unclear. The aim of this study was to evaluate the causal effect of OSA on atrial fibrillation. METHODS AND RESULTS: We used a 2‐sample Mendelian randomization (MR) method to evaluate the causal effect of OSA on atrial fibrillation. Summary data on genetic variant‐OSA association were obtained from a recently published genome‐wide association studies with up to 217 955 individuals and data on variant‐atrial fibrillation association from another genome‐wide association study with up to 1 030 836 individuals. Effect estimates were evaluated using inverse‐variance weighted method. Other MR analyses, including penalized inverse‐variance weighted, penalized robust inverse‐variance weighted, MR‐Egger, simple median, weighted median, weighted mode‐based estimate and Mendelian Randomization Pleiotropy Residual Sum and Outlier methods were performed in sensitivity analyses. The MR analyses in both the fixed‐effect and random‐effect inverse‐variance weighted models showed that genetically predicted OSA was associated with an increased risk of atrial fibrillation (odds ratio [OR], 1.21; 95% CI, 1.12–1.31, P<0.001; OR, 1.21; 95% CI, 1.11–1.32, P<0.001) using 5 single nucleotide polymorphisms as the instruments. MR‐Egger indicated no evidence of genetic pleiotropy (intercept, −0.014; 95% CI, −0.033 to 0.005, P=0.14). Results were robust using other MR methods in sensitivity analyses. CONCLUSIONS: This MR analysis found that genetically predicted OSA had causal effect on an increased risk of atrial fibrillation. John Wiley and Sons Inc. 2021-11-19 /pmc/articles/PMC9075405/ /pubmed/34796736 http://dx.doi.org/10.1161/JAHA.121.022560 Text en © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Chen, Weiqi
Cai, Xueli
Yan, Hongyi
Pan, Yuesong
Causal Effect of Obstructive Sleep Apnea on Atrial Fibrillation: A Mendelian Randomization Study
title Causal Effect of Obstructive Sleep Apnea on Atrial Fibrillation: A Mendelian Randomization Study
title_full Causal Effect of Obstructive Sleep Apnea on Atrial Fibrillation: A Mendelian Randomization Study
title_fullStr Causal Effect of Obstructive Sleep Apnea on Atrial Fibrillation: A Mendelian Randomization Study
title_full_unstemmed Causal Effect of Obstructive Sleep Apnea on Atrial Fibrillation: A Mendelian Randomization Study
title_short Causal Effect of Obstructive Sleep Apnea on Atrial Fibrillation: A Mendelian Randomization Study
title_sort causal effect of obstructive sleep apnea on atrial fibrillation: a mendelian randomization study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075405/
https://www.ncbi.nlm.nih.gov/pubmed/34796736
http://dx.doi.org/10.1161/JAHA.121.022560
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