Cargando…

Cardiovagal Function Measured by the Deep Breathing Test: Relationships With Coronary Atherosclerosis

BACKGROUND: The cardiovagal function can be assessed by quantification of respiratory sinus arrhythmia (RSA) during a deep breathing test. However, population studies of RSA and coronary atherosclerosis are lacking. This population‐based study examined the relationship between RSA during deep breath...

Descripción completa

Detalles Bibliográficos
Autores principales: Engström, Gunnar, Hamrefors, Viktor, Fedorowski, Artur, Persson, Anders, Johansson, Maria E., Ostenfeld, Ellen, Goncalves, Isabel, Markstad, Hanna, Johnson, Linda S. B., Persson, Margaretha, Carlson, Jonas, Platonov, Pyotr G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075454/
https://www.ncbi.nlm.nih.gov/pubmed/35352566
http://dx.doi.org/10.1161/JAHA.121.024053
_version_ 1784701687854792704
author Engström, Gunnar
Hamrefors, Viktor
Fedorowski, Artur
Persson, Anders
Johansson, Maria E.
Ostenfeld, Ellen
Goncalves, Isabel
Markstad, Hanna
Johnson, Linda S. B.
Persson, Margaretha
Carlson, Jonas
Platonov, Pyotr G.
author_facet Engström, Gunnar
Hamrefors, Viktor
Fedorowski, Artur
Persson, Anders
Johansson, Maria E.
Ostenfeld, Ellen
Goncalves, Isabel
Markstad, Hanna
Johnson, Linda S. B.
Persson, Margaretha
Carlson, Jonas
Platonov, Pyotr G.
author_sort Engström, Gunnar
collection PubMed
description BACKGROUND: The cardiovagal function can be assessed by quantification of respiratory sinus arrhythmia (RSA) during a deep breathing test. However, population studies of RSA and coronary atherosclerosis are lacking. This population‐based study examined the relationship between RSA during deep breathing and coronary atherosclerosis, assessed by coronary artery calcium score (CACS). METHODS AND RESULTS: SCAPIS (Swedish Cardiopulmonary Bioimage Study) randomly invited men and women aged 50 to 64 years from the general population. CACS was obtained from computed tomography scanning, and deep breathing tests were performed in 4654 individuals. Expiration–inspiration differences (E‐Is) of heart rates were calculated, and reduced RSA was defined as E‐I in the lowest decile of the population. The relationship between reduced RSA and CACS (CACS≥100 or CACS≥300) was calculated using multivariable‐adjusted logistic regression. The proportion of CACS≥100 was 24% in the lowest decile of E‐I and 12% in individuals with E‐I above the lowest decile (P<0.001), and the proportion of CACS≥300 was 12% and 4.8%, respectively (P<0.001). The adjusted odds ratio (OR) for CACS≥100 was 1.42 (95% CI, 1.10–1.84) and the adjusted OR for CACS≥300 was 1.62 (95% CI, 1.15–2.28), when comparing the lowest E‐I decile with deciles 2 to 10. Adjusted ORs per 1 SD lower E‐I were 1.17 (P=0.001) for CACS≥100 and 1.28 (P=0.001) for CACS≥300. CONCLUSIONS: Low RSA during deep breathing is associated with increased coronary atherosclerosis as assessed by CACS, independently of traditional cardiovascular risk factors. Cardiovagal dysfunction could be a prevalent and modifiable risk factor for coronary atherosclerosis in the general population.
format Online
Article
Text
id pubmed-9075454
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-90754542022-05-10 Cardiovagal Function Measured by the Deep Breathing Test: Relationships With Coronary Atherosclerosis Engström, Gunnar Hamrefors, Viktor Fedorowski, Artur Persson, Anders Johansson, Maria E. Ostenfeld, Ellen Goncalves, Isabel Markstad, Hanna Johnson, Linda S. B. Persson, Margaretha Carlson, Jonas Platonov, Pyotr G. J Am Heart Assoc Original Research BACKGROUND: The cardiovagal function can be assessed by quantification of respiratory sinus arrhythmia (RSA) during a deep breathing test. However, population studies of RSA and coronary atherosclerosis are lacking. This population‐based study examined the relationship between RSA during deep breathing and coronary atherosclerosis, assessed by coronary artery calcium score (CACS). METHODS AND RESULTS: SCAPIS (Swedish Cardiopulmonary Bioimage Study) randomly invited men and women aged 50 to 64 years from the general population. CACS was obtained from computed tomography scanning, and deep breathing tests were performed in 4654 individuals. Expiration–inspiration differences (E‐Is) of heart rates were calculated, and reduced RSA was defined as E‐I in the lowest decile of the population. The relationship between reduced RSA and CACS (CACS≥100 or CACS≥300) was calculated using multivariable‐adjusted logistic regression. The proportion of CACS≥100 was 24% in the lowest decile of E‐I and 12% in individuals with E‐I above the lowest decile (P<0.001), and the proportion of CACS≥300 was 12% and 4.8%, respectively (P<0.001). The adjusted odds ratio (OR) for CACS≥100 was 1.42 (95% CI, 1.10–1.84) and the adjusted OR for CACS≥300 was 1.62 (95% CI, 1.15–2.28), when comparing the lowest E‐I decile with deciles 2 to 10. Adjusted ORs per 1 SD lower E‐I were 1.17 (P=0.001) for CACS≥100 and 1.28 (P=0.001) for CACS≥300. CONCLUSIONS: Low RSA during deep breathing is associated with increased coronary atherosclerosis as assessed by CACS, independently of traditional cardiovascular risk factors. Cardiovagal dysfunction could be a prevalent and modifiable risk factor for coronary atherosclerosis in the general population. John Wiley and Sons Inc. 2022-03-30 /pmc/articles/PMC9075454/ /pubmed/35352566 http://dx.doi.org/10.1161/JAHA.121.024053 Text en © 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Engström, Gunnar
Hamrefors, Viktor
Fedorowski, Artur
Persson, Anders
Johansson, Maria E.
Ostenfeld, Ellen
Goncalves, Isabel
Markstad, Hanna
Johnson, Linda S. B.
Persson, Margaretha
Carlson, Jonas
Platonov, Pyotr G.
Cardiovagal Function Measured by the Deep Breathing Test: Relationships With Coronary Atherosclerosis
title Cardiovagal Function Measured by the Deep Breathing Test: Relationships With Coronary Atherosclerosis
title_full Cardiovagal Function Measured by the Deep Breathing Test: Relationships With Coronary Atherosclerosis
title_fullStr Cardiovagal Function Measured by the Deep Breathing Test: Relationships With Coronary Atherosclerosis
title_full_unstemmed Cardiovagal Function Measured by the Deep Breathing Test: Relationships With Coronary Atherosclerosis
title_short Cardiovagal Function Measured by the Deep Breathing Test: Relationships With Coronary Atherosclerosis
title_sort cardiovagal function measured by the deep breathing test: relationships with coronary atherosclerosis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075454/
https://www.ncbi.nlm.nih.gov/pubmed/35352566
http://dx.doi.org/10.1161/JAHA.121.024053
work_keys_str_mv AT engstromgunnar cardiovagalfunctionmeasuredbythedeepbreathingtestrelationshipswithcoronaryatherosclerosis
AT hamreforsviktor cardiovagalfunctionmeasuredbythedeepbreathingtestrelationshipswithcoronaryatherosclerosis
AT fedorowskiartur cardiovagalfunctionmeasuredbythedeepbreathingtestrelationshipswithcoronaryatherosclerosis
AT perssonanders cardiovagalfunctionmeasuredbythedeepbreathingtestrelationshipswithcoronaryatherosclerosis
AT johanssonmariae cardiovagalfunctionmeasuredbythedeepbreathingtestrelationshipswithcoronaryatherosclerosis
AT ostenfeldellen cardiovagalfunctionmeasuredbythedeepbreathingtestrelationshipswithcoronaryatherosclerosis
AT goncalvesisabel cardiovagalfunctionmeasuredbythedeepbreathingtestrelationshipswithcoronaryatherosclerosis
AT markstadhanna cardiovagalfunctionmeasuredbythedeepbreathingtestrelationshipswithcoronaryatherosclerosis
AT johnsonlindasb cardiovagalfunctionmeasuredbythedeepbreathingtestrelationshipswithcoronaryatherosclerosis
AT perssonmargaretha cardiovagalfunctionmeasuredbythedeepbreathingtestrelationshipswithcoronaryatherosclerosis
AT carlsonjonas cardiovagalfunctionmeasuredbythedeepbreathingtestrelationshipswithcoronaryatherosclerosis
AT platonovpyotrg cardiovagalfunctionmeasuredbythedeepbreathingtestrelationshipswithcoronaryatherosclerosis