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Wnt Site Signaling Inhibitor Secreted Frizzled‐Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction–Induced Endothelial‐to‐Mesenchymal Transition

BACKGROUND: The onset and mechanisms of endothelial‐to‐mesenchymal transition (EndMT) in mitral valve (MV) leaflets following myocardial infarction (MI) are unknown, yet these events are closely linked to stiffening of leaflets and development of ischemic mitral regurgitation. We investigated whethe...

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Detalles Bibliográficos
Autores principales:	Alvandi, Zahra, Nagata, Yasufumi, Passos, Livia Silva Araúujo, Hashemi Gheinani, Ali, Guerrero, J. Luis, Wylie‐Sears, Jill, Romero, Dayana Carolina, Morris, Brittan A., Sullivan, Suzanne M., Yaghoubian, Koushiar M., Alvandi, Amirhossein, Adam, Rosalyn M., Aikawa, Elena, Levine, Robert A., Bischoff, Joyce
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075477/ https://www.ncbi.nlm.nih.gov/pubmed/35348006 http://dx.doi.org/10.1161/JAHA.121.023695

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