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A selective and sensitive UFLC-MS/MS method for the simultaneous determination of five alkaloids from Piper longum L. and its application in the pharmacokinetic study of 6-OHDA-induced Parkinson's disease rats

The alkaloids from Piper longum L. (PLA) mainly contain piperine (PPR), piperlongumine (PPL), Δα,β-dihydropiperlonguminine (DPPL), piperanine (PPRA) and pellitorine (PLTR), which have neuroprotective effects on a 6-OHDA-induced rat model of Parkinson's disease (PD). To elucidate the pharmacokin...

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Detalles Bibliográficos
Autores principales:	Xu, Rongrong, Zhao, Wenwen, Yu, Lan, Chen, Qijun, Hu, Xiaolu, Ba, Yinying, Chen, Xiaoqing, Wang, Xing, Wu, Xia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075506/ https://www.ncbi.nlm.nih.gov/pubmed/35539049 http://dx.doi.org/10.1039/c9ra06325k

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