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Differential mitochondrial protein interaction profile between human translocator protein and its A147T polymorphism variant
The translocator protein (TSPO) has been implicated in mitochondrial transmembrane cholesterol transport, brain inflammation, and other mitochondrial functions. It is upregulated in glial cells during neuroinflammation in Alzheimer’s disease. High affinity TSPO imaging radioligands are utilized to v...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075623/ https://www.ncbi.nlm.nih.gov/pubmed/35522669 http://dx.doi.org/10.1371/journal.pone.0254296 |