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Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki–Miyaura reaction

The Suzuki–Miyaura reaction is one of the most used transformations in drug research. Thus making this reaction more sustainable is of considerable current interest. Here we show that propylene carbonate (PC) can be used as a solvent for the Suzuki–Miyaura reaction. PC is one of the greenest solvent...

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Detalles Bibliográficos
Autores principales: Czompa, Andrea, Pásztor, Balázs László, Sahar, Jennifer Alizadeh, Mucsi, Zoltán, Bogdán, Dóra, Ludányi, Krisztina, Varga, Zoltán, Mándity, István M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075783/
https://www.ncbi.nlm.nih.gov/pubmed/35541805
http://dx.doi.org/10.1039/c9ra07044c
Descripción
Sumario:The Suzuki–Miyaura reaction is one of the most used transformations in drug research. Thus making this reaction more sustainable is of considerable current interest. Here we show that propylene carbonate (PC) can be used as a solvent for the Suzuki–Miyaura reaction. PC is one of the greenest solvents since it is synthesized under green conditions by the use of carbon dioxide in the air. All reactions proceeded well and good or excellent yields were observed for the biaryl products. Nonetheless in the case of pyridazinones, 2-hydroxypropyl- chain containing side-products were observed. Importantly, this fact allowed the isolation of several novel compounds which were generated under prominently green conditions.