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Nanobody assemblies with fully flexible topology enabled by genetically encoded tetrazine amino acids

Assembling nanobodies (Nbs) into polyvalent multimers is a powerful strategy for improving the effectiveness of Nb-based therapeutics and biotechnological tools. However, generally effective approaches to Nb assembly are currently restricted to the amino or carboxyl termini, greatly limiting the div...

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Detalles Bibliográficos
Autores principales:	Van Fossen, Elise M., Bednar, Riley M., Jana, Subhashis, Franklin, Rachel, Beckman, Joseph, Karplus, P. Andrew, Mehl, Ryan A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075797/ https://www.ncbi.nlm.nih.gov/pubmed/35522749 http://dx.doi.org/10.1126/sciadv.abm6909

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