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Efficient detection of a biomarker for infant jaundice by a europium(iii)-organic framework luminescence sensor
Efficient detection of excess bilirubin in human serum and urine is highly important for the early diagnosis of infant jaundice. A highly stable Eu(iii)-based microporous framework with bent {Eu(COO)} chains interconnected by pairs of T-shaped 4,4′-(4,4′-bipyridine-2,6-diyl)dibenzoate (bpydb(2−)) li...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075806/ https://www.ncbi.nlm.nih.gov/pubmed/35542293 http://dx.doi.org/10.1039/c9ra08604h |
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author | Xu, Ping Yang, Han-Wen Shi, Jia-Li Ding, Bo Zhao, Xiao-Jun Yang, En-Cui |
author_facet | Xu, Ping Yang, Han-Wen Shi, Jia-Li Ding, Bo Zhao, Xiao-Jun Yang, En-Cui |
author_sort | Xu, Ping |
collection | PubMed |
description | Efficient detection of excess bilirubin in human serum and urine is highly important for the early diagnosis of infant jaundice. A highly stable Eu(iii)-based microporous framework with bent {Eu(COO)} chains interconnected by pairs of T-shaped 4,4′-(4,4′-bipyridine-2,6-diyl)dibenzoate (bpydb(2−)) linkers, {[Eu(H(2)O)(HCOO)(bpydb)]·solvent}(n) (1), was solvothermally synthesized and used as a chemical sensor for bilirubin response under clinically-applicable visible-light excitation. Due to the significant synergetic effect of the inner filter effect and photoinduced electron transfer, 1 can effectively probe trace amounts of bilirubin in aqueous solution through fluorescence decay with a strong quenching constant of 6.40 × 10(4) M(−1) and low detection limit of 1.75 μM. More importantly, a portable test paper made from 1 was further developed to achieve qualitative, naked-eye visualized differentiation for the biomarker in clinical applications. These interesting findings highlight the importance of the π-conjugated antenna ligand for clinically applicable Ln-MOF sensors. |
format | Online Article Text |
id | pubmed-9075806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90758062022-05-09 Efficient detection of a biomarker for infant jaundice by a europium(iii)-organic framework luminescence sensor Xu, Ping Yang, Han-Wen Shi, Jia-Li Ding, Bo Zhao, Xiao-Jun Yang, En-Cui RSC Adv Chemistry Efficient detection of excess bilirubin in human serum and urine is highly important for the early diagnosis of infant jaundice. A highly stable Eu(iii)-based microporous framework with bent {Eu(COO)} chains interconnected by pairs of T-shaped 4,4′-(4,4′-bipyridine-2,6-diyl)dibenzoate (bpydb(2−)) linkers, {[Eu(H(2)O)(HCOO)(bpydb)]·solvent}(n) (1), was solvothermally synthesized and used as a chemical sensor for bilirubin response under clinically-applicable visible-light excitation. Due to the significant synergetic effect of the inner filter effect and photoinduced electron transfer, 1 can effectively probe trace amounts of bilirubin in aqueous solution through fluorescence decay with a strong quenching constant of 6.40 × 10(4) M(−1) and low detection limit of 1.75 μM. More importantly, a portable test paper made from 1 was further developed to achieve qualitative, naked-eye visualized differentiation for the biomarker in clinical applications. These interesting findings highlight the importance of the π-conjugated antenna ligand for clinically applicable Ln-MOF sensors. The Royal Society of Chemistry 2019-11-19 /pmc/articles/PMC9075806/ /pubmed/35542293 http://dx.doi.org/10.1039/c9ra08604h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Xu, Ping Yang, Han-Wen Shi, Jia-Li Ding, Bo Zhao, Xiao-Jun Yang, En-Cui Efficient detection of a biomarker for infant jaundice by a europium(iii)-organic framework luminescence sensor |
title | Efficient detection of a biomarker for infant jaundice by a europium(iii)-organic framework luminescence sensor |
title_full | Efficient detection of a biomarker for infant jaundice by a europium(iii)-organic framework luminescence sensor |
title_fullStr | Efficient detection of a biomarker for infant jaundice by a europium(iii)-organic framework luminescence sensor |
title_full_unstemmed | Efficient detection of a biomarker for infant jaundice by a europium(iii)-organic framework luminescence sensor |
title_short | Efficient detection of a biomarker for infant jaundice by a europium(iii)-organic framework luminescence sensor |
title_sort | efficient detection of a biomarker for infant jaundice by a europium(iii)-organic framework luminescence sensor |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075806/ https://www.ncbi.nlm.nih.gov/pubmed/35542293 http://dx.doi.org/10.1039/c9ra08604h |
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