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Non-natural 2H-azirine-2-carboxylic acids: an expedient synthesis and antimicrobial activity
Non-natural 2H-azirine-2-carboxylic acids were obtained in high yields by FeCl(2)-catalyzed isomerization of 5-chloroisoxazoles to azirine-2-carbonyl chlorides followed by their hydrolysis. The 3-aryl- and 3-heteroaryl-substituted acids are stable during prolonged storage, exhibit antibacterial acti...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075858/ https://www.ncbi.nlm.nih.gov/pubmed/35541773 http://dx.doi.org/10.1039/c9ra09345a |
Sumario: | Non-natural 2H-azirine-2-carboxylic acids were obtained in high yields by FeCl(2)-catalyzed isomerization of 5-chloroisoxazoles to azirine-2-carbonyl chlorides followed by their hydrolysis. The 3-aryl- and 3-heteroaryl-substituted acids are stable during prolonged storage, exhibit antibacterial activity against ESKAPE pathogens and show a low level of cytotoxicity. |
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