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Investigation of The Effect of Curcumin on Oxidative Stress, Local Inflammatory Response, COX-2 Expression, and Microvessel Density in Trichinella Spiralis Induced Enteritis, Myositis and Myocarditis in Mice

BACKGROUND: Curcumin exerts anti-oxidant and anti-inflammatory properties that have proven to be of value in the management of several parasitic infections. OBJECTIVE: Investigation of the value of curcumin in the management of trichinosis either alone or as an adjuvant to albendazole. METHODS: Anim...

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Autores principales: Hamed, A. M. R., Abdel-Shafi, I. R., Elsayed, M. D. A., Mahfoz, A. M., Tawfeek, S. E., Abdeltawab, M. S. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sciendo 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075878/
https://www.ncbi.nlm.nih.gov/pubmed/35601760
http://dx.doi.org/10.2478/helm-2022-0002
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author Hamed, A. M. R.
Abdel-Shafi, I. R.
Elsayed, M. D. A.
Mahfoz, A. M.
Tawfeek, S. E.
Abdeltawab, M. S. A.
author_facet Hamed, A. M. R.
Abdel-Shafi, I. R.
Elsayed, M. D. A.
Mahfoz, A. M.
Tawfeek, S. E.
Abdeltawab, M. S. A.
author_sort Hamed, A. M. R.
collection PubMed
description BACKGROUND: Curcumin exerts anti-oxidant and anti-inflammatory properties that have proven to be of value in the management of several parasitic infections. OBJECTIVE: Investigation of the value of curcumin in the management of trichinosis either alone or as an adjuvant to albendazole. METHODS: Animals received either curcumin 150 mg/kg, curcumin 300 mg/kg, albendazole 50 mg/ kg or combined curcumin 150mg/kg and albendazole 50 mg/kg and were compared with control infected and non-infected mice. Estimation of intestinal and muscular parasitic load and blood malondialdehyde level, in addition to the histopathological examination of small intestine, skeletal muscle tissue and heart was performed. Also, assessment of the local expression of cyclooxygenase-2 enzyme (COX-2) and CD34 in these samples was done by immunohistochemistry. RESULTS: Curcumin was found efficient in reducing parasitic load. It also lowered serum MDA level, local COX-2 and CD34 expression. An evident anti-inflammatory effect of curcumin was observed in intestinal, skeletal muscle and cardiac muscle histopathological sections. CONCLUSION: The anti-inflammatory, anti-oxidant and anti-angiogenic effects of curcumin can help to improve trichinellosis-induced pathology. Curcumin can therefore be of value as an adjuvant therapy to conventional antiparasitic agents and can also produce promising results when used alone at higher doses.
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spelling pubmed-90758782022-05-21 Investigation of The Effect of Curcumin on Oxidative Stress, Local Inflammatory Response, COX-2 Expression, and Microvessel Density in Trichinella Spiralis Induced Enteritis, Myositis and Myocarditis in Mice Hamed, A. M. R. Abdel-Shafi, I. R. Elsayed, M. D. A. Mahfoz, A. M. Tawfeek, S. E. Abdeltawab, M. S. A. Helminthologia Research Article BACKGROUND: Curcumin exerts anti-oxidant and anti-inflammatory properties that have proven to be of value in the management of several parasitic infections. OBJECTIVE: Investigation of the value of curcumin in the management of trichinosis either alone or as an adjuvant to albendazole. METHODS: Animals received either curcumin 150 mg/kg, curcumin 300 mg/kg, albendazole 50 mg/ kg or combined curcumin 150mg/kg and albendazole 50 mg/kg and were compared with control infected and non-infected mice. Estimation of intestinal and muscular parasitic load and blood malondialdehyde level, in addition to the histopathological examination of small intestine, skeletal muscle tissue and heart was performed. Also, assessment of the local expression of cyclooxygenase-2 enzyme (COX-2) and CD34 in these samples was done by immunohistochemistry. RESULTS: Curcumin was found efficient in reducing parasitic load. It also lowered serum MDA level, local COX-2 and CD34 expression. An evident anti-inflammatory effect of curcumin was observed in intestinal, skeletal muscle and cardiac muscle histopathological sections. CONCLUSION: The anti-inflammatory, anti-oxidant and anti-angiogenic effects of curcumin can help to improve trichinellosis-induced pathology. Curcumin can therefore be of value as an adjuvant therapy to conventional antiparasitic agents and can also produce promising results when used alone at higher doses. Sciendo 2022-05-04 /pmc/articles/PMC9075878/ /pubmed/35601760 http://dx.doi.org/10.2478/helm-2022-0002 Text en © 2022 A. M. R. Hamed, I. R. Abdel-Shafi, M. D. A. Elsayed, A. M. Mahfoz, S. E. Tawfeek, M. S. A. Abdeltawab, published by Sciendo https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Research Article
Hamed, A. M. R.
Abdel-Shafi, I. R.
Elsayed, M. D. A.
Mahfoz, A. M.
Tawfeek, S. E.
Abdeltawab, M. S. A.
Investigation of The Effect of Curcumin on Oxidative Stress, Local Inflammatory Response, COX-2 Expression, and Microvessel Density in Trichinella Spiralis Induced Enteritis, Myositis and Myocarditis in Mice
title Investigation of The Effect of Curcumin on Oxidative Stress, Local Inflammatory Response, COX-2 Expression, and Microvessel Density in Trichinella Spiralis Induced Enteritis, Myositis and Myocarditis in Mice
title_full Investigation of The Effect of Curcumin on Oxidative Stress, Local Inflammatory Response, COX-2 Expression, and Microvessel Density in Trichinella Spiralis Induced Enteritis, Myositis and Myocarditis in Mice
title_fullStr Investigation of The Effect of Curcumin on Oxidative Stress, Local Inflammatory Response, COX-2 Expression, and Microvessel Density in Trichinella Spiralis Induced Enteritis, Myositis and Myocarditis in Mice
title_full_unstemmed Investigation of The Effect of Curcumin on Oxidative Stress, Local Inflammatory Response, COX-2 Expression, and Microvessel Density in Trichinella Spiralis Induced Enteritis, Myositis and Myocarditis in Mice
title_short Investigation of The Effect of Curcumin on Oxidative Stress, Local Inflammatory Response, COX-2 Expression, and Microvessel Density in Trichinella Spiralis Induced Enteritis, Myositis and Myocarditis in Mice
title_sort investigation of the effect of curcumin on oxidative stress, local inflammatory response, cox-2 expression, and microvessel density in trichinella spiralis induced enteritis, myositis and myocarditis in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075878/
https://www.ncbi.nlm.nih.gov/pubmed/35601760
http://dx.doi.org/10.2478/helm-2022-0002
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