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Magnetically targeted nanoparticles for imaging-guided photothermal therapy of cancer
Over the past several decades, nanocarriers have constituted a vital research area for accurate tumor therapy. Herein, magnetically targeted nanoparticles (IRFes) for photothermal therapy were generated by integrating IR780, a molecule with strong emission and absorption in the NIR spectrum and the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075904/ https://www.ncbi.nlm.nih.gov/pubmed/35541810 http://dx.doi.org/10.1039/c9ra08281f |
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author | Chen, Sijie Huang, Biying Pei, Wenjing Xu, Yan Jiang, Zichao Li, Jingyi Wang, Long Niu, Chengcheng |
author_facet | Chen, Sijie Huang, Biying Pei, Wenjing Xu, Yan Jiang, Zichao Li, Jingyi Wang, Long Niu, Chengcheng |
author_sort | Chen, Sijie |
collection | PubMed |
description | Over the past several decades, nanocarriers have constituted a vital research area for accurate tumor therapy. Herein, magnetically targeted nanoparticles (IRFes) for photothermal therapy were generated by integrating IR780, a molecule with strong emission and absorption in the NIR spectrum and the ability to produce heat after laser irradiation, with Fe(3)O(4) nanoparticles (NPs). These IRFes were guided to the tumor site by the application of an external magnetic field. In particular, the strong NIR absorption of IR780 was used for NIRF imaging, and we also demonstrated effective magnetic targeting for the photothermal ablation of tumors. In vitro cell viability and in vivo antitumor experiments showed that these IRFes can ablate 4T1 cells or transplanted 4T1 cell tumors when exposed to 808 nm laser irradiation and a magnetic field. In vivo experiments showed that IRFes only act on tumors, do not damage other organs and can be used to image tumors. These results demonstrate the enormous potential of local photothermal therapy for cancer under the guidance of external magnetic fields and reveal the prospect for the use of multifunctional nanoparticles in tumor therapy. |
format | Online Article Text |
id | pubmed-9075904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90759042022-05-09 Magnetically targeted nanoparticles for imaging-guided photothermal therapy of cancer Chen, Sijie Huang, Biying Pei, Wenjing Xu, Yan Jiang, Zichao Li, Jingyi Wang, Long Niu, Chengcheng RSC Adv Chemistry Over the past several decades, nanocarriers have constituted a vital research area for accurate tumor therapy. Herein, magnetically targeted nanoparticles (IRFes) for photothermal therapy were generated by integrating IR780, a molecule with strong emission and absorption in the NIR spectrum and the ability to produce heat after laser irradiation, with Fe(3)O(4) nanoparticles (NPs). These IRFes were guided to the tumor site by the application of an external magnetic field. In particular, the strong NIR absorption of IR780 was used for NIRF imaging, and we also demonstrated effective magnetic targeting for the photothermal ablation of tumors. In vitro cell viability and in vivo antitumor experiments showed that these IRFes can ablate 4T1 cells or transplanted 4T1 cell tumors when exposed to 808 nm laser irradiation and a magnetic field. In vivo experiments showed that IRFes only act on tumors, do not damage other organs and can be used to image tumors. These results demonstrate the enormous potential of local photothermal therapy for cancer under the guidance of external magnetic fields and reveal the prospect for the use of multifunctional nanoparticles in tumor therapy. The Royal Society of Chemistry 2019-11-21 /pmc/articles/PMC9075904/ /pubmed/35541810 http://dx.doi.org/10.1039/c9ra08281f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Chen, Sijie Huang, Biying Pei, Wenjing Xu, Yan Jiang, Zichao Li, Jingyi Wang, Long Niu, Chengcheng Magnetically targeted nanoparticles for imaging-guided photothermal therapy of cancer |
title | Magnetically targeted nanoparticles for imaging-guided photothermal therapy of cancer |
title_full | Magnetically targeted nanoparticles for imaging-guided photothermal therapy of cancer |
title_fullStr | Magnetically targeted nanoparticles for imaging-guided photothermal therapy of cancer |
title_full_unstemmed | Magnetically targeted nanoparticles for imaging-guided photothermal therapy of cancer |
title_short | Magnetically targeted nanoparticles for imaging-guided photothermal therapy of cancer |
title_sort | magnetically targeted nanoparticles for imaging-guided photothermal therapy of cancer |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075904/ https://www.ncbi.nlm.nih.gov/pubmed/35541810 http://dx.doi.org/10.1039/c9ra08281f |
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