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Determination of microcystins in water samples by deep eutectic solvent-based vortex-assisted liquid–liquid microextraction coupled with ultrahigh-performance liquid chromatography-high resolution mass spectrometry
Rapid screening of two microcystins (i.e., microcystin-YR (MC-YR) and microcystin-LR (MC-LR)) in surface water samples was performed by a simple and eco-friendly procedure using deep eutectic solvent-based vortex-assisted liquid–liquid microextraction (DES-based VALLME) combined with ultrahigh-perfo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075955/ https://www.ncbi.nlm.nih.gov/pubmed/35540236 http://dx.doi.org/10.1039/c9ra07544e |
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author | Chen, Yung-Chih Ao, Yi-Ting Ding, Wang-Hsien |
author_facet | Chen, Yung-Chih Ao, Yi-Ting Ding, Wang-Hsien |
author_sort | Chen, Yung-Chih |
collection | PubMed |
description | Rapid screening of two microcystins (i.e., microcystin-YR (MC-YR) and microcystin-LR (MC-LR)) in surface water samples was performed by a simple and eco-friendly procedure using deep eutectic solvent-based vortex-assisted liquid–liquid microextraction (DES-based VALLME) combined with ultrahigh-performance liquid chromatography and electrospray ionization (+)-quadrupole time-of-flight mass spectrometry (UHPLC-ESI(+)-qTOF-MS) detection. To obtain an efficient water-miscible DES, choline chloride and phenol at a molar ratio of 1 : 2 were used as an extractant for VALLME. To optimize factors of DES-based VALLME, response surface design alongside Box–Behnken design was used. The limits of quantitation (LOQs) were 0.5 ng mL(−1) and 0.4 ng mL(−1) for MC-YR and MC-LR, respectively, which is sensitive enough to meet the World Health Organization (WHO) maximum guideline level for MC-LR in water of 1.0 ng mL(−1). Moreover, satisfactory precision with relative standard deviations (RSD) for both intra- and inter-day analysis lower than 11%, and trueness (also known as mean extraction recovery) ranged from 85.5 to 113% based on the ICH method validation guideline. |
format | Online Article Text |
id | pubmed-9075955 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90759552022-05-09 Determination of microcystins in water samples by deep eutectic solvent-based vortex-assisted liquid–liquid microextraction coupled with ultrahigh-performance liquid chromatography-high resolution mass spectrometry Chen, Yung-Chih Ao, Yi-Ting Ding, Wang-Hsien RSC Adv Chemistry Rapid screening of two microcystins (i.e., microcystin-YR (MC-YR) and microcystin-LR (MC-LR)) in surface water samples was performed by a simple and eco-friendly procedure using deep eutectic solvent-based vortex-assisted liquid–liquid microextraction (DES-based VALLME) combined with ultrahigh-performance liquid chromatography and electrospray ionization (+)-quadrupole time-of-flight mass spectrometry (UHPLC-ESI(+)-qTOF-MS) detection. To obtain an efficient water-miscible DES, choline chloride and phenol at a molar ratio of 1 : 2 were used as an extractant for VALLME. To optimize factors of DES-based VALLME, response surface design alongside Box–Behnken design was used. The limits of quantitation (LOQs) were 0.5 ng mL(−1) and 0.4 ng mL(−1) for MC-YR and MC-LR, respectively, which is sensitive enough to meet the World Health Organization (WHO) maximum guideline level for MC-LR in water of 1.0 ng mL(−1). Moreover, satisfactory precision with relative standard deviations (RSD) for both intra- and inter-day analysis lower than 11%, and trueness (also known as mean extraction recovery) ranged from 85.5 to 113% based on the ICH method validation guideline. The Royal Society of Chemistry 2019-11-26 /pmc/articles/PMC9075955/ /pubmed/35540236 http://dx.doi.org/10.1039/c9ra07544e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Chen, Yung-Chih Ao, Yi-Ting Ding, Wang-Hsien Determination of microcystins in water samples by deep eutectic solvent-based vortex-assisted liquid–liquid microextraction coupled with ultrahigh-performance liquid chromatography-high resolution mass spectrometry |
title | Determination of microcystins in water samples by deep eutectic solvent-based vortex-assisted liquid–liquid microextraction coupled with ultrahigh-performance liquid chromatography-high resolution mass spectrometry |
title_full | Determination of microcystins in water samples by deep eutectic solvent-based vortex-assisted liquid–liquid microextraction coupled with ultrahigh-performance liquid chromatography-high resolution mass spectrometry |
title_fullStr | Determination of microcystins in water samples by deep eutectic solvent-based vortex-assisted liquid–liquid microextraction coupled with ultrahigh-performance liquid chromatography-high resolution mass spectrometry |
title_full_unstemmed | Determination of microcystins in water samples by deep eutectic solvent-based vortex-assisted liquid–liquid microextraction coupled with ultrahigh-performance liquid chromatography-high resolution mass spectrometry |
title_short | Determination of microcystins in water samples by deep eutectic solvent-based vortex-assisted liquid–liquid microextraction coupled with ultrahigh-performance liquid chromatography-high resolution mass spectrometry |
title_sort | determination of microcystins in water samples by deep eutectic solvent-based vortex-assisted liquid–liquid microextraction coupled with ultrahigh-performance liquid chromatography-high resolution mass spectrometry |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9075955/ https://www.ncbi.nlm.nih.gov/pubmed/35540236 http://dx.doi.org/10.1039/c9ra07544e |
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