Excited-state locked amino analogues of the green fluorescent protein chromophore with a giant Stokes shift

We design a novel class of excited-state locked GFP chromophores by introducing an amine group at the double exo-bond and a difluoroboryl bridge. We show that these chromophores intrinsically exhibit a very large Stokes shift of 1 eV. Further tuning through chemical modifications of their aryl subst...

Descripción completa

Detalles Bibliográficos
Autores principales: Zaitseva, Snizhana O., Farkhutdinova, Dilara A., Baleeva, Nadezhda S., Smirnov, Alexander Yu., Zagudaylova, Marina B., Shakhov, Aleksander M., Astafiev, Artyom A., Baranov, Mikhail S., Bochenkova, Anastasia V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076007/
https://www.ncbi.nlm.nih.gov/pubmed/35540244
http://dx.doi.org/10.1039/c9ra08808c
Descripción
Sumario:We design a novel class of excited-state locked GFP chromophores by introducing an amine group at the double exo-bond and a difluoroboryl bridge. We show that these chromophores intrinsically exhibit a very large Stokes shift of 1 eV. Further tuning through chemical modifications of their aryl substituents makes them environmentally sensitive.

Ejemplares similares