Microwave-assisted synthesis of 7-azaindoles via iron-catalyzed cyclization of an o-haloaromatic amine with terminal alkynes

An efficient and practical procedure was developed to prepare 7-azaindole, starting from an o-haloaromatic amine and corresponding terminal alkynes under microwave irradiation and the scope was demonstrated with a number of examples. The valuable features of this procedure included the iron-catalyze...

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Detalles Bibliográficos
Autores principales: Le, Yi, Yang, Zhisong, Chen, Yumei, Chen, Dongmei, Yan, Longjia, Wang, Zhenchao, Ouyang, Guiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076099/
https://www.ncbi.nlm.nih.gov/pubmed/35541389
http://dx.doi.org/10.1039/c9ra08742g
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author Le, Yi
Yang, Zhisong
Chen, Yumei
Chen, Dongmei
Yan, Longjia
Wang, Zhenchao
Ouyang, Guiping
author_facet Le, Yi
Yang, Zhisong
Chen, Yumei
Chen, Dongmei
Yan, Longjia
Wang, Zhenchao
Ouyang, Guiping
author_sort Le, Yi
collection PubMed
description An efficient and practical procedure was developed to prepare 7-azaindole, starting from an o-haloaromatic amine and corresponding terminal alkynes under microwave irradiation and the scope was demonstrated with a number of examples. The valuable features of this procedure included the iron-catalyzed cyclization, short reaction times and convenient operation. Furthermore, iron catalysis is an interesting alternative to homogeneous catalysis for the synthesis of heterocycles.
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spelling pubmed-90760992022-05-09 Microwave-assisted synthesis of 7-azaindoles via iron-catalyzed cyclization of an o-haloaromatic amine with terminal alkynes Le, Yi Yang, Zhisong Chen, Yumei Chen, Dongmei Yan, Longjia Wang, Zhenchao Ouyang, Guiping RSC Adv Chemistry An efficient and practical procedure was developed to prepare 7-azaindole, starting from an o-haloaromatic amine and corresponding terminal alkynes under microwave irradiation and the scope was demonstrated with a number of examples. The valuable features of this procedure included the iron-catalyzed cyclization, short reaction times and convenient operation. Furthermore, iron catalysis is an interesting alternative to homogeneous catalysis for the synthesis of heterocycles. The Royal Society of Chemistry 2019-12-02 /pmc/articles/PMC9076099/ /pubmed/35541389 http://dx.doi.org/10.1039/c9ra08742g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Le, Yi
Yang, Zhisong
Chen, Yumei
Chen, Dongmei
Yan, Longjia
Wang, Zhenchao
Ouyang, Guiping
Microwave-assisted synthesis of 7-azaindoles via iron-catalyzed cyclization of an o-haloaromatic amine with terminal alkynes
title Microwave-assisted synthesis of 7-azaindoles via iron-catalyzed cyclization of an o-haloaromatic amine with terminal alkynes
title_full Microwave-assisted synthesis of 7-azaindoles via iron-catalyzed cyclization of an o-haloaromatic amine with terminal alkynes
title_fullStr Microwave-assisted synthesis of 7-azaindoles via iron-catalyzed cyclization of an o-haloaromatic amine with terminal alkynes
title_full_unstemmed Microwave-assisted synthesis of 7-azaindoles via iron-catalyzed cyclization of an o-haloaromatic amine with terminal alkynes
title_short Microwave-assisted synthesis of 7-azaindoles via iron-catalyzed cyclization of an o-haloaromatic amine with terminal alkynes
title_sort microwave-assisted synthesis of 7-azaindoles via iron-catalyzed cyclization of an o-haloaromatic amine with terminal alkynes
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076099/
https://www.ncbi.nlm.nih.gov/pubmed/35541389
http://dx.doi.org/10.1039/c9ra08742g
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