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Quinoline-triazole hybrids inhibit falcipain-2 and arrest the development of Plasmodium falciparum at the trophozoite stage

Falcipain-2 (FP2) is a papain family cysteine protease and a key member of the hemoglobin degradation pathway, a process that is required at erythrocytic stages of Plasmodium falciparum to obtain amino acids. In this study, we report a set of 10 quinoline-triazole-based compounds (T1–T10) which exhi...

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Detalles Bibliográficos
Autores principales: Singh, Anju, Kalamuddin, Md, Mohmmed, Asif, Malhotra, Pawan, Hoda, Nasimul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076119/
https://www.ncbi.nlm.nih.gov/pubmed/35540629
http://dx.doi.org/10.1039/c9ra06571g

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