Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action

Dienone compounds have been demonstrated to display tumor-selective anti-cancer activity independently of the mutational status of TP53. Previous studies have shown that cell death elicited by this class of compounds is associated with inhibition of the ubiquitin-proteasome system (UPS). Here we ext...

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Detalles Bibliográficos
Autores principales: Gubat, Johannes, Selvaraju, Karthik, Sjöstrand, Linda, Kumar Singh, Dhananjay, Turkina, Maria V., Schmierer, Bernhard, Sabatier, Pierre, Zubarev, Roman A., Linder, Stig, D’Arcy, Pádraig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076133/
https://www.ncbi.nlm.nih.gov/pubmed/35530310
http://dx.doi.org/10.3389/fonc.2022.852980

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