Selective recognition of human telomeric G-quadruplex with designed peptide via hydrogen bonding followed by base stacking interactions

We described a novel synthetic peptide in which a glutamine residue binds through hydrogen bonding to a guanine-base and a trytophan residue intercalates with K(+) resulting in stabilization of a human telomeric G-quadruplex with high selectivity over its complementary c-rich strand and a double-str...

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Detalles Bibliográficos
Autores principales: Tyagi, Shikhar, Saxena, Sarika, Kundu, Nikita, Sharma, Taniya, Chakraborty, Amlan, Kaur, Sarvpreet, Miyoshi, Daisuke, Shankaraswamy, Jadala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076235/
https://www.ncbi.nlm.nih.gov/pubmed/35542665
http://dx.doi.org/10.1039/c9ra08761c

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