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Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a T(1) MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity
A simple and efficient method to synthesize highly water-dispersible calcium lignosulfonate-coated manganese oxide nanoparticles as a potential candidate for the current magnetic resonance imaging (MRI) T(1) contrast agents was reported. Hydrophobic MnO nanoparticles with dimensions of about 10 nm w...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076238/ https://www.ncbi.nlm.nih.gov/pubmed/35542658 http://dx.doi.org/10.1039/c9ra09125d |
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author | Arian, Mahdi Zamanian, Ali Taheri, Salman |
author_facet | Arian, Mahdi Zamanian, Ali Taheri, Salman |
author_sort | Arian, Mahdi |
collection | PubMed |
description | A simple and efficient method to synthesize highly water-dispersible calcium lignosulfonate-coated manganese oxide nanoparticles as a potential candidate for the current magnetic resonance imaging (MRI) T(1) contrast agents was reported. Hydrophobic MnO nanoparticles with dimensions of about 10 nm were prepared by thermal decomposition of manganese(ii)acetylacetonate in the presence of oleic acid as a surfactant. The characteristics of the synthesized nanoparticles, cytotoxicity assay and in vitro MRI properties were investigated in detail. Results showed that calcium lignosulfonate has a great influence on the colloidal stability and biocompatibility of MnO nanoparticles in water. Furthermore, this coating agent ensures abundant exposure of external Mn ion with protons of water, which endows the nanoparticles with a longitudinal molar relaxivity (r(1)) of 4.62 mM(−1) s(−1). An efficient contrast enhancement effect was observed in the study of MRI investigations. |
format | Online Article Text |
id | pubmed-9076238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90762382022-05-09 Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a T(1) MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity Arian, Mahdi Zamanian, Ali Taheri, Salman RSC Adv Chemistry A simple and efficient method to synthesize highly water-dispersible calcium lignosulfonate-coated manganese oxide nanoparticles as a potential candidate for the current magnetic resonance imaging (MRI) T(1) contrast agents was reported. Hydrophobic MnO nanoparticles with dimensions of about 10 nm were prepared by thermal decomposition of manganese(ii)acetylacetonate in the presence of oleic acid as a surfactant. The characteristics of the synthesized nanoparticles, cytotoxicity assay and in vitro MRI properties were investigated in detail. Results showed that calcium lignosulfonate has a great influence on the colloidal stability and biocompatibility of MnO nanoparticles in water. Furthermore, this coating agent ensures abundant exposure of external Mn ion with protons of water, which endows the nanoparticles with a longitudinal molar relaxivity (r(1)) of 4.62 mM(−1) s(−1). An efficient contrast enhancement effect was observed in the study of MRI investigations. The Royal Society of Chemistry 2019-12-06 /pmc/articles/PMC9076238/ /pubmed/35542658 http://dx.doi.org/10.1039/c9ra09125d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Arian, Mahdi Zamanian, Ali Taheri, Salman Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a T(1) MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity |
title | Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a T(1) MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity |
title_full | Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a T(1) MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity |
title_fullStr | Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a T(1) MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity |
title_full_unstemmed | Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a T(1) MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity |
title_short | Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a T(1) MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity |
title_sort | highly water-dispersible calcium lignosulfonate-capped mno nanoparticles as a t(1) mri contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076238/ https://www.ncbi.nlm.nih.gov/pubmed/35542658 http://dx.doi.org/10.1039/c9ra09125d |
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