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Lanthanide-doped mesoporous MCM-41 nanoparticles as a novel optical–magnetic multifunctional nanobioprobe

To research and develop potential multifunctional nanoprobes for biological application, lanthanide-doped MCM-41 (Ln-MCM-41, Ln = Gd/Eu) silica nanoparticles with excellent pore structure and optical–magnetic properties were synthesized via a facile and economical sol–gel method. The microstructure...

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Autores principales: Liu, Jun, Liu, Siqian, Li, Yaling, Xue, Jiayan, He, Youyi, Liu, Fuchi, Yang, Li, Hu, Junhui, Xiong, Zhengye, Long, Lizhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076282/
https://www.ncbi.nlm.nih.gov/pubmed/35540093
http://dx.doi.org/10.1039/c9ra08116j
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author Liu, Jun
Liu, Siqian
Li, Yaling
Xue, Jiayan
He, Youyi
Liu, Fuchi
Yang, Li
Hu, Junhui
Xiong, Zhengye
Long, Lizhen
author_facet Liu, Jun
Liu, Siqian
Li, Yaling
Xue, Jiayan
He, Youyi
Liu, Fuchi
Yang, Li
Hu, Junhui
Xiong, Zhengye
Long, Lizhen
author_sort Liu, Jun
collection PubMed
description To research and develop potential multifunctional nanoprobes for biological application, lanthanide-doped MCM-41 (Ln-MCM-41, Ln = Gd/Eu) silica nanoparticles with excellent pore structure and optical–magnetic properties were synthesized via a facile and economical sol–gel method. The microstructure and pore distribution of Ln-MCM-41 nanoparticles were obviously affected by the Ln-doping. As the Ln/Si mole ratio increased, the specific surface area and total pore volume of Ln-MCM-41 nanoparticles rapidly decreased. However, the Ln-MCM-41 nanoparticles still retained the typical well-ordered mesoporous structure, and exhibited excellent drug release behavior. Moreover, the drug release rate of Ln-MCM-41 was remarkably pH-dependent and increased gradually upon decreasing pH. Additionally, these nanoparticles also exhibit considerable photoluminescence properties, living cells photoluminescence imaging in vitro, and paramagnetism behavior at room temperature due to the Ln(3+)-ions doping. Our research shows the possibility of our Ln-MCM-41 nanoparticles as multifunctional nanoprobes for application in bioseparation, bioimaging, and drug delivery.
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spelling pubmed-90762822022-05-09 Lanthanide-doped mesoporous MCM-41 nanoparticles as a novel optical–magnetic multifunctional nanobioprobe Liu, Jun Liu, Siqian Li, Yaling Xue, Jiayan He, Youyi Liu, Fuchi Yang, Li Hu, Junhui Xiong, Zhengye Long, Lizhen RSC Adv Chemistry To research and develop potential multifunctional nanoprobes for biological application, lanthanide-doped MCM-41 (Ln-MCM-41, Ln = Gd/Eu) silica nanoparticles with excellent pore structure and optical–magnetic properties were synthesized via a facile and economical sol–gel method. The microstructure and pore distribution of Ln-MCM-41 nanoparticles were obviously affected by the Ln-doping. As the Ln/Si mole ratio increased, the specific surface area and total pore volume of Ln-MCM-41 nanoparticles rapidly decreased. However, the Ln-MCM-41 nanoparticles still retained the typical well-ordered mesoporous structure, and exhibited excellent drug release behavior. Moreover, the drug release rate of Ln-MCM-41 was remarkably pH-dependent and increased gradually upon decreasing pH. Additionally, these nanoparticles also exhibit considerable photoluminescence properties, living cells photoluminescence imaging in vitro, and paramagnetism behavior at room temperature due to the Ln(3+)-ions doping. Our research shows the possibility of our Ln-MCM-41 nanoparticles as multifunctional nanoprobes for application in bioseparation, bioimaging, and drug delivery. The Royal Society of Chemistry 2019-12-10 /pmc/articles/PMC9076282/ /pubmed/35540093 http://dx.doi.org/10.1039/c9ra08116j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Liu, Jun
Liu, Siqian
Li, Yaling
Xue, Jiayan
He, Youyi
Liu, Fuchi
Yang, Li
Hu, Junhui
Xiong, Zhengye
Long, Lizhen
Lanthanide-doped mesoporous MCM-41 nanoparticles as a novel optical–magnetic multifunctional nanobioprobe
title Lanthanide-doped mesoporous MCM-41 nanoparticles as a novel optical–magnetic multifunctional nanobioprobe
title_full Lanthanide-doped mesoporous MCM-41 nanoparticles as a novel optical–magnetic multifunctional nanobioprobe
title_fullStr Lanthanide-doped mesoporous MCM-41 nanoparticles as a novel optical–magnetic multifunctional nanobioprobe
title_full_unstemmed Lanthanide-doped mesoporous MCM-41 nanoparticles as a novel optical–magnetic multifunctional nanobioprobe
title_short Lanthanide-doped mesoporous MCM-41 nanoparticles as a novel optical–magnetic multifunctional nanobioprobe
title_sort lanthanide-doped mesoporous mcm-41 nanoparticles as a novel optical–magnetic multifunctional nanobioprobe
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076282/
https://www.ncbi.nlm.nih.gov/pubmed/35540093
http://dx.doi.org/10.1039/c9ra08116j
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