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Intermittent Hypoxia Inhibits Hepatic CYP1a2 Expression and Delays Aminophylline Metabolism

PURPOSE: In this study, we aimed to determine the effects of intermittent hypoxia (IH) on hepatic cytochrome P450 1A2 (CYP1A2) expression and the pharmacokinetics of CYP1A2-mediated aminophylline and warfarin in vitro and in a rabbit model of obstructive sleep apnea. MATERIALS: Human normal liver (L...

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Detalles Bibliográficos
Autores principales:	Zhang, Xiao-Bin, Chen, Xiao-Yang, Chiu, Kam Yu, He, Xiu-Zhen, Wang, Jian-Ming, Zeng, Hui-Qing, Zeng, Yiming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076297/ https://www.ncbi.nlm.nih.gov/pubmed/35529917 http://dx.doi.org/10.1155/2022/2782702

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