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Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models

The lack of inadequate preclinical models remains a limitation for cancer drug development and is a primary contributor to anti-cancer drug failures in clinical trials. Heterotypic multicellular spheroids are three-dimensional (3D) spherical structures generated by self-assembly from aggregates of t...

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Detalles Bibliográficos
Autores principales:	Lotsberg, Maria L., Røsland, Gro V., Rayford, Austin J., Dyrstad, Sissel E., Ekanger, Camilla T., Lu, Ning, Frantz, Kirstine, Stuhr, Linda E. B., Ditzel, Henrik J., Thiery, Jean Paul, Akslen, Lars A., Lorens, James B., Engelsen, Agnete S. T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076321/ https://www.ncbi.nlm.nih.gov/pubmed/35530312 http://dx.doi.org/10.3389/fonc.2022.818437

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