The Ag-promoted α-C–H arylation of alcohols

We herein report the functionalization of α-C–H in alcohols through cross-dehydrogenative coupling reactions. Selectfluor was used as a mild oxidant. In situ-generated HF participated in the reaction and no external strong acid was necessary. A variety of heteroaryl-substituted alcohols were achieve...

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Detalles Bibliográficos
Autores principales: Wang, Shoufeng, Xing, Shuya, Zhang, Yingying, Fan, Yafei, Zhao, Huaiqing, Wang, Jianfeng, Zhang, Shuxiang, Wang, Wengui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076519/
https://www.ncbi.nlm.nih.gov/pubmed/35541603
http://dx.doi.org/10.1039/c9ra09954a
Descripción
Sumario:We herein report the functionalization of α-C–H in alcohols through cross-dehydrogenative coupling reactions. Selectfluor was used as a mild oxidant. In situ-generated HF participated in the reaction and no external strong acid was necessary. A variety of heteroaryl-substituted alcohols were achieved with good yields and with good functional group tolerance.

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