Access to 1-amino-3,4-dihydroisoquinolines via palladium-catalyzed C–H bond aminoimidoylation reaction from functionalized isocyanides

Efficient access to 1-amino-3,4-dihydroisoquinolines, through palladium-catalyzed intramolecular C–H bond aminoimidoylation of α-benzyl-α-isocyanoacetates, has been developed. Consecutive isocyanide insertion and C–H bond activation were realized with C–N and C–C bonds formation in one step under re...

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Autores principales: Xiong, Zhuang, Cai, Panyuan, Mei, Yingshuang, Wang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076523/
https://www.ncbi.nlm.nih.gov/pubmed/35542878
http://dx.doi.org/10.1039/c9ra09139d
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author Xiong, Zhuang
Cai, Panyuan
Mei, Yingshuang
Wang, Jian
author_facet Xiong, Zhuang
Cai, Panyuan
Mei, Yingshuang
Wang, Jian
author_sort Xiong, Zhuang
collection PubMed
description Efficient access to 1-amino-3,4-dihydroisoquinolines, through palladium-catalyzed intramolecular C–H bond aminoimidoylation of α-benzyl-α-isocyanoacetates, has been developed. Consecutive isocyanide insertion and C–H bond activation were realized with C–N and C–C bonds formation in one step under redox neutral conditions, employing O-benzoyl hydroxylamines as electrophilic amino sources.
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spelling pubmed-90765232022-05-09 Access to 1-amino-3,4-dihydroisoquinolines via palladium-catalyzed C–H bond aminoimidoylation reaction from functionalized isocyanides Xiong, Zhuang Cai, Panyuan Mei, Yingshuang Wang, Jian RSC Adv Chemistry Efficient access to 1-amino-3,4-dihydroisoquinolines, through palladium-catalyzed intramolecular C–H bond aminoimidoylation of α-benzyl-α-isocyanoacetates, has been developed. Consecutive isocyanide insertion and C–H bond activation were realized with C–N and C–C bonds formation in one step under redox neutral conditions, employing O-benzoyl hydroxylamines as electrophilic amino sources. The Royal Society of Chemistry 2019-12-18 /pmc/articles/PMC9076523/ /pubmed/35542878 http://dx.doi.org/10.1039/c9ra09139d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Xiong, Zhuang
Cai, Panyuan
Mei, Yingshuang
Wang, Jian
Access to 1-amino-3,4-dihydroisoquinolines via palladium-catalyzed C–H bond aminoimidoylation reaction from functionalized isocyanides
title Access to 1-amino-3,4-dihydroisoquinolines via palladium-catalyzed C–H bond aminoimidoylation reaction from functionalized isocyanides
title_full Access to 1-amino-3,4-dihydroisoquinolines via palladium-catalyzed C–H bond aminoimidoylation reaction from functionalized isocyanides
title_fullStr Access to 1-amino-3,4-dihydroisoquinolines via palladium-catalyzed C–H bond aminoimidoylation reaction from functionalized isocyanides
title_full_unstemmed Access to 1-amino-3,4-dihydroisoquinolines via palladium-catalyzed C–H bond aminoimidoylation reaction from functionalized isocyanides
title_short Access to 1-amino-3,4-dihydroisoquinolines via palladium-catalyzed C–H bond aminoimidoylation reaction from functionalized isocyanides
title_sort access to 1-amino-3,4-dihydroisoquinolines via palladium-catalyzed c–h bond aminoimidoylation reaction from functionalized isocyanides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076523/
https://www.ncbi.nlm.nih.gov/pubmed/35542878
http://dx.doi.org/10.1039/c9ra09139d
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